陕西职业学校视力残疾学生患非酒精性脂肪肝病及临床实验室相关指标调查  

An Investigation of Non-alcoholic Fatty Liver and Clinical Laboratoryrelated Indicators in Shaanxi Province’s Vocational Students with Visual Disabilities

作　　者：商静 刘波[1] 李小侠[2] 王珍芳[1] 张茜茜 郭振军 SHANG Jing;LIU Bo;LI Xiao-xia;WANG Zhen-fang;ZHANG Xi-xi;GUO Zhen-jun(Ultrasound Medical Diagnosis Center,Shaanxi Provincial People’s Hospital,Xi’an 710068,China;Department of Clinical Laboratory,Shaanxi Provincial People’s Hospital,Xi’an 710068,China;Department of Pharmacy,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)

机构地区：[1]陕西省人民医院超声诊断中心,西安710068 [2]陕西省人民医院检验科,西安710068 [3]陕西省人民医院药学部,西安710068

出　　处：《现代检验医学杂志》2023年第3期199-203,共5页Journal of Modern Laboratory Medicine

基　　金：陕西省人民医院科技人才支持计划(2022JY-22)。

摘　　要：目的调查陕西职业学校视力残疾学生非酒精性脂肪肝病(non-alcoholic fatty liver,NAFL)患病现状及相关临床实验室指标。方法2021年10月对陕西省城市经济学校视力残疾学生集中进行了健康体检,根据肝脏超声结果分为NAFL组(n=15)和健康组(n=51)。比较两组间NAFL相关体格测量及实验室指标差异,并采用二元Logistic回归方法分析影响NAFL发生的独立危险因素。结果66例(男38例,女28例)15~35(22±5)岁视力残疾学生的NAFL患病率为22.7%。NAFL组学生的体重指数25.5±4.9 kg/m^(2),腰围83(77,97)cm,收缩压128.4±18.8mmHg,舒张压88±9mmHg,三酰甘油1.9(1.1,2.3)mmol/L,总胆固醇5.0(4.8,5.5)mmol/L,门冬氨酸氨基转移酶27(19,37)U/L,丙氨酸氨基转移酶27(21,34)U/L及尿酸449.0(386.0,512.0)mmol/L显著高于健康组[(21.2±2.7kg/m^(2),74(70,79)cm,117.8±14.5 mmHg,80±13 mmHg,0.9(0.8,1.5)mmol/L,3.8(3.4,4.2)mmol/L,17(15,21)U/L,13(10,18)U/L,370.5(299.3,424.3)mmol/L],差异具有统计学意义(t=-4.4~-2.3,U=128.5~215.5,均P<0.05)。二元Logistic回归分析显示体重指数(OR=1.6,P=0.002)和三酰甘油(OR=2.4,P=0.002)差异具有统计学意义。结论陕西省职业学校视力残疾学生NAFL患病率较高,体重指数和三酰甘油是发生NAFL的独立危险因素。Objective To investigate the present prevalence of non-alcoholic fatty liver(NAFL)and its associated laboratory indexes in Shaanxi vocational school students with visual impairment.Methods A survey on the prevalence of NAFL was done in October 2021 among visually disabled vocational students in Shaanxi Urban Economy School.According to the results of liver ultrasound,all subjects were assigned to the NAFL group(n=15)and the health group(n=51).The physical measurements and laboratory index differences between the two groups,and the binary logistic regression was used to analyze the NAFL-related influencing factors.Results Sixty-six students with a mean age of 22 were examined,including 38 males and 28 females who aged from 15 to 35.The prevalence of NALL among these students was 22.7%.NAFL students had higher values of body mass index 25.5±4.9kg/m^(2),waist circumference 83(77,97)cm,systolic blood pressure 128.4±18.8 mmHg,diastolic blood pressure 88±9 mmHg,triglycerides 1.9(1.1,2.3)mmol/L,total cholesterol 5.0(4.8,5.5)mmol/L,aspartate aminotransferase 27(19,37)U/L,alanine aminotransferase 27(21,34)U/L and uric acid 449.0(386.0,512.0)mmol/L than healthy students[(21.2±2.7kg/m^(2),74(70,79)cm,117.8±14.5 mmHg,80±13 mmHg,0.9(0.8,1.5)mmol/L,3.8(3.4,4.2)mmol/L,17(15,21)U/L,13(10,18)U/L,370.5(299.3,424.3)mmol/L],and the differences were statistically significant(t=-4.4~-2.3,U=128.5~215.5,all P<0.05).Binary logistic regression analysis showed that both body mass index(OR=1.6,P=0.002)and triacylglycerol(OR=2.4,P=0.002)were characteristic variables that affected the state of NAFL.Conclusion The prevalence of NAFL among students with visual disability in vocational schools in Shaanxi Province is high.The body mass index and triacylglycerol are independent risk factors for NAFL.

关 键 词：非酒精性脂肪肝病 视力残疾 学生 

分 类 号：R575.5[医药卫生—消化系统] R446.11[医药卫生—内科学]