Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release  

作　　者：Xiaowei MAO Kexin CHEN Yanlong ZHAO Chunrong Xiong Jing LUO Yuguang WANG Bo WANG Hongyu ZHANG 

机构地区：[1]School of Chemical Engineering and Technology,Hainan University,Haikou 570228,China [2]State Key Laboratory of Tribology,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China [3]Peking University School of Nursing&National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing 100191,China [4]Beijing Research Institute of Automation for Machinery Industry Co.,Ltd.,Beijing 100120,China [5]Center of Digital Dentistry,Peking University School and Hospital of Stomatology&NHC Research Center of Engineering and Technology for Computerized Dentistry,Beijing 100081,China [6]College of Chemical and Biological Engineering,Shandong University of Science and Technology,Qingdao 266590,China

出　　处：《Friction》2023年第7期1194-1211,共18页摩擦（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(52022043 and 21868011);Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program(20191080593);Precision Medicine Foundation,Tsinghua University,China(10001020107);the National Key R&D Program of China(2017YFC1103800);Research Fund of State Key Laboratory of Tribology,Tsinghua University,China(SKLT2022C18).

摘　　要：Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis.In the present study,bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages,a biomimetic self-adhesive dopamine methacrylamide-poly(2-methacryloyloxyethyl phosphorylcholine)(DMA-MPC)copolymer was designed and synthesized via free radical polymerization.The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles(bMSNs)by the dip-coating method to prepare the dual-functional nanoparticles(bMSNs@DMA-MPC),which were evaluated using a series of surface characterizations including the transmission electron microscope(TEM),Fourier transform infrared(FTIR)spectrum,thermogravimetric analysis(TGA),X-ray photoelectron spectroscopy(XPS),etc.The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug,i.e.,diclofenac sodium(DS).In addition,the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d.Furthermore,the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β(IL-1β)and interleukin-6(IL-6).In summary,the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

关 键 词：surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication OSTEOARTHRITIS 

分 类 号：TQ127.2[化学工程—无机化工] TB383.1[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]