稀土掺杂上转换纳米材料在兽药残留检测领域的应用  

Application of Rare Earth Doped Upconversion Nanomaterials in The Field of Veterinary Drug Residue Detection

作　　者：孟颖 殷慧 彭微 白安琪 罗利霞 李淑荣[1,2] 孟佩俊 Meng Ying;Yin Hui;Peng Wei;Bai Anqi;Luo Lixia;Li Shurong;Meng Pejun(Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology;Engineering Technology Center of Hygienic Inspection and Assessment of Inner Mongolia Autonomous Region,Baotou,014040)

机构地区：[1]内蒙古科技大学包头医学院公共卫生学院 [2]内蒙古自治区卫生检测与评价工程技术中心,包头014040

出　　处：《化学通报》2023年第5期551-558,534,共9页Chemistry

基　　金：国家自然科学基金项目(81960601);内蒙古自治区自然科学基金项目(2021MS08055);内蒙古自治区卫生健康委医疗卫生科技计划项目(202201383)资助。

摘　　要：食品和环境中兽药残留问题时有发生,对人类健康构成很大的潜在威胁。随着人们对美好生活和同一健康的向往和不断追求,对微量甚至痕量兽药残留的分析检测已显得日益迫切和重要。因此,构建对兽药残留进行灵敏、准确、稳定、简便、快速检测的方法已成为一个热点研究领域。稀土掺杂上转换纳米材料(REEs-UCNPs)作为一种新兴的纳米荧光材料,具有独特的反斯托克斯发光性质,由于其具有荧光寿命长、光散射小、激发光生物组织穿透深度大且对组织损伤小等显著优点,在分析检测领域逐步凸显出巨大优势。本文重点介绍了基于REEs-UCNPs构建荧光共振能量转移核酸适配体传感器、磁性纳米颗粒结合核酸装配体传感器、荧光免疫探针以及现场快速检测等在兽药残留检测方面的研究进展,并对其应用前景进行了探讨和展望。Veterinary drug residues in the food and the environment occur from time to time,posing a great potential threat to human health.With people""s yearning for a better life and the One Health,the analysis and detection of trace or even trace veterinary drug residues has become increasingly urgent and important.Therefore,it has become a hot research field to construct a sensitive,accurate,stable,simple and rapid detection method for veterinary drug residues.As an emerging nano-fluorescent material,rare earth doped upconversion nanomaterials(REEs-UCNPs)have unique anti-Stokes luminescence properties,and because of their significant advantages such as long fluorescence life,small light scattering,large penetration depth of excitation light biological tissues and small damage to tissues,they have gradually highlighted great advantages in the field of analysis and detection.This paper focuses on the research progress in the detection of veterinary drug residues by constructing the fluorescence resonance energy transfer nucleic acid aptamer sensor,magnetic nanoparticles combined with nucleic acid assembly sensor,fluorescence immunoprobe and on-site rapid detection based on REEs-UCNPs,and discusses and prospects its application prospects.

关 键 词：稀土掺杂上转换纳米材料 兽药残留 核酸适配体 荧光免疫法 快速检测 

分 类 号：S859.84[农业科学—临床兽医学] TB383.1[农业科学—兽医学]