胆碱与中枢神经系统发育及相关疾病的基础研究进展  

Advances in basic research on choline and central nervous system development and related disorders

作　　者：夏正龙 谭栩颖 宋燕燕[1] Xia Zhenglong;Tan Xuying;Song Yanyan(Department of Child Health Care,Guangzhou Women and Children′s Medical Center,Guangzhou Medical University,Guangzhou 510623,China)

机构地区：[1]广州医科大学附属广州市妇女儿童医疗中心儿童保健部,广州510623

出　　处：《中华预防医学杂志》2023年第5期793-800,共8页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(82003431);广东省科技厅科技计划项目(2017A020214002);广州市合生元营养与护理研究院“母婴营养与护理研究基金项目”(2020BINCMCF047)。

摘　　要：胆碱是人体必需的营养素,在生命周期的所有阶段均起着不可或缺的作用,其中胆碱与神经发育之间的关系日益受到关注。胆碱是合成磷脂、磷脂酰胆碱和鞘磷脂的主要成分,是甲基代谢、乙酰胆碱合成和细胞信号转导的重要营养素。胆碱在胎儿发育过程中的神经发生和神经迁移中起着重要作用,潜在影响神经系统疾病的发生及预后,但其作用机制尚未明确。本文就胆碱的来源与代谢、胆碱对神经发育、中枢神经系统相关疾病的影响及机制进行阐述。Choline is an essential nutrient that plays an integral role in all stages of the life cycle,with increasing interest in the relationship between choline and neurodevelopment.Choline is a major component in the synthesis of phospholipids,phosphatidylcholine and sphingolipids,and is an essential nutrient for methyl metabolism,acetylcholine synthesis and cell signaling.Choline plays an important role in neurogenesis and neural migration during fetal development,potentially influencing the development and prognosis of neurological disorders,but its mechanism of action is not yet clear.This article reviews the source and metabolism of choline,the effects and mechanism of choline on neurodevelopment and central nervous system related disorders.

关 键 词：胆碱 中枢神经系统 发育 中枢神经系统疾病 认知功能 

分 类 号：R741[医药卫生—神经病学与精神病学]