Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities  

作　　者：Ping Wang Yue Wang Ping Li Chen Chen Siman Ma Linxuan Zhao Haibing He Tian Yin Yu Zhang Xing Tang Jingxin Gou 

机构地区：[1]Department of Pharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China [2]School of Pharmacy,Jilin University,Changchun 130021,China [3]School of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Chinese Chemical Letters》2023年第4期99-109,共11页中国化学快报（英文版）

基　　金：supported by the National Key R&D Program of China (No. 2020YFE0201700);the National Mega-project for Innovative Drugs (No. 2019ZX09721001);the National Natural Science Foundation of China (No. 81673378);the Liaoning Revitalization Talents Program (No. XLYC1908031);the Project of Liaoning Provincial Department of Education (No. 2019LQN07);the PhD Research Startup Foundation of Liaoning Province (No. 2020-BS-128)。

摘　　要：Efficient oral delivery of drugs treating brain diseases has long been a challenging topic faced by the drug delivery community. Fortunately, polyester nanoparticles offer certain solutions to this problem. This review article firstly describes the main obstacles faced by oral administered brain targeting, including:(1)instability in the gastrointestinal tract;(2) poor penetration of the intestinal mucosa and epithelium;(3)blood clearance;and(4) restriction by the BBB. Then the key factors influencing brain-targeting efficiency of orally administered polyester nanoparticles are also discussed, such as size, shape and surface properties. Finally, recent brain-targeting delivery strategies using oral polyester nanoparticles as carriers and their effects on brain drugs transport are reviewed, and the delivery ‘as a whole’ strategy of polyester nanoparticles will provide new insight for oral brain-targeting delivery. And by combination of multiple strategies, both the stability and permeability of polyester nanoparticles can be greatly improved for oral brain drug delivery.

关 键 词：Polyester nanoparticles Oral brain drugs Brain-targeted delivery Physiological barrier Absorption enhancement 

分 类 号：R741[医药卫生—神经病学与精神病学]