Hydrogen-bond locked purine chromophores with high photostability for lipid droplets imaging in cells and tissues  

作　　者：Jinlin Zhou Kun Li Lei Shi Hong Zhang Haoyuan Wang Yimin Shan Shanyong Chen Xiao-Qi Yu 

机构地区：[1]Key Laboratory of Green Chemistry and Technology,Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China [2]State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610064,China [3]Department of Chemistry,Xihua University,Chengdu 610039,China

出　　处：《Chinese Chemical Letters》2023年第4期300-303,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (Nos. 22077088, 21877082,U21A20308);the Foundation from the Science and Technology Department of Sichuan Province (Nos. 2020JDJQ0017,2021YFH0132, 2020ZHCG0097)。

摘　　要：Recently, hydrogen-bonding has attracted extensive attention in the design of chromophores. Here, a new class of hydrogen-bond locked purine chromophores(HOPs) were reported by introducing a hydroxyphenyl group into the C(6) position of purine. The intramolecular hydrogen bond plays a dominant role to light up these probes. As a bonus, HOPs show high photostability. Moreover, HOPs exhibit remarkable capability for the specific lipid droplets imaging in living cells with excellent biocompatibility and are also potential for diagnosing fatty liver diseases. These results bring important new insights into the photophysics of the purine-based chromophores and provide a new scaffold with high photostability for bioimaging.

关 键 词：Fluorescent probe PURINE Hydrogen bond Lipid droplets Fatty liver 

分 类 号：R313[医药卫生—基础医学] O657.3[理学—分析化学]