SCC-Ag、CEA及CA125测定对早期宫颈癌诊断价值  

Determination of squamous cell carcinoma antigen、carcinoembryonic antigen and carbohydrate antigen-125 in the diagnosis of early cervical cancer

作　　者：许少花 卓可秀 XU Shaohua;ZHUO Kexiu(Cangnan County Third People's Hospital,Zhejang 325804,China)

机构地区：[1]浙江省苍南县第三人民医院,苍南325804 [2]龙港市人民医院

出　　处：《浙江创伤外科》2023年第5期833-835,839,共4页Zhejiang Journal of Traumatic Surgery

摘　　要：目的 通过检测血清鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)及糖类抗原-125(CA125)水平来探讨其对早期宫颈癌的诊断价值,为临床早期治疗干预提供参考依据。方法 选取2021年1月至2022年12月医院120例研究对象进行分组,根据疾病类型分成3组,其中健康体检者30例(对照组)、宫颈上皮内瘤变-CIN 30例(A组)以及宫颈癌患者60例(B组)。检测并比较三组空腹下血清鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)及糖类抗原-125(CA125)水平。同时分析不同肿瘤标志物单项或联合检测在诊断宫颈癌中的效果。结果 B组患者血清SCC-Ag水平为(10.42±2.74)μg/L、CEA水平为(9.82±1.74)μg/L、CA125水平为(60.14±6.47) U/mL,明显高于A组患者血清SCC-Ag水平为(1.82±0.32)μg/L、CEA水平为(4.57±0.63)μg/L、CA125水平为(32.25±7.81) U/mL以及对照组血清SCC-Ag水平为(0.85±0.17)μg/L、CEA水平为(1.32±0.21)μg/L、CA125水平为(17.63±2.58) U/mL,P<0.05。A组各项肿瘤标志物水平明显高于对照组,P<0.05。单项检测肿瘤标志物诊断早期宫颈癌的灵敏度、特异度以及准确度无明显差异,P>0.05。联合检测三项肿瘤标志物诊断早期宫颈癌的灵敏度、特异度以及准确度,明显高于单独检测肿瘤标志物的灵敏度、特异度以及准确度,P<0.05。结论 临床可通过检测血清鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)及糖类抗原-125(CA125)水平可有助于临床判断患者疾病恶变程度,同时联合检测可提高诊断准确度和灵敏度,从而为临床及早干预提供参考依据。Objective To investigate the diagnostic value of serum squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA) and carbohydrate antigen-125(CA125) levels in early cervical cancer,and to provide reference basis for clinical early treatment and intervention.Methods 120 subjects from the hospital from December 2021 to December 2022 were divided into three groups according to the type of disease,including 30 healthy persons(control group),30 cases of cervical intraepithelial neoplasia-CIN(group A) and 60 cases of cervical cancer(group B).The levels of serum SCC-Ag,CEA and CA125 were measured and compared in three groups.At the same time,the effect of single or com-bined detection of different tumor markers in the diagnosis of cervical cancer was analyzed.Results The levels of serum SCC-Ag was(10.42±2.74)μg/L,CEA was(9.82±1.74) μg/L and CA125 was(60.14±6.47) U/mL in group B,(1.82±0.32) μg/L,(4.57±0.63) μg/L,(32.25±7.81) U/mL in group A respectively,and(0.85±0.17) μg/L,(1.32±0.21) μg/L in control group respectively.The level of tumor markers in group B was significantly higher than those in group A(P<0.05).The level of tumor markers in group A was significantly higher than those in control group( P<0.05).There was no significant difference in the sensitivity,specificity and accuracy of single detection of tumor markers in the diagnosis of early cervical cancer( P>0.05).The sensitivity,specificity and accuracy of combined detection of three tumor markers in the diagnosis of early cervical cancer were significantly high-er than that of single detection of tumor markers(P<0.05).Conclusion The detection of SCC-Ag,CEA and CA125 can help to determine the degree of malignant change in patients,and the combined detection can improve the diagnostic accuracy and sensitivity,thus providing a reference basis for early clinical intervention.

关 键 词：鳞状细胞癌抗原(SCC-Ag) 癌胚抗原(CEA) 糖类抗原-125(CA125) 早期 宫颈癌 

分 类 号：R737.3[医药卫生—肿瘤]