SCAMP2在结直肠癌中的表达及其意义  

EXPRESSION AND SIGNIFICANCE OF SECRETORY CARRIER MEMBRANE PROTEIN 2 IN COLORECTAL CANCER

作　　者：乔业华 郭栋[2] 王璐[1] 曲婷婷[3] 张翔雁 邢晓明[3] QIAO Yehua;GUO Dong;WANG Lu;QU Tingting;ZHANG Xiangyan;XING Xiaoming(Department of Pathology,School of Basic Medicine,Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学基础医学院病理学系,山东青岛266071 [2]青岛大学附属医院胃肠外科 [3]青岛大学附属医院病理科

出　　处：《精准医学杂志》2023年第3期241-244,共4页Journal of Precision Medicine

基　　金：国家自然科学基金面上项目(81972329)。

摘　　要：目的 探讨分泌载体膜蛋白2(SCAMP2)在结直肠癌(colorectal cancer, CRC)中的表达及其意义。方法 收集2014年1月—2016年8月青岛大学附属医院309例原发性CRC患者的石蜡组织样本及临床病理资料,采用免疫组织化学法检测SCAMP2在CRC组织及癌旁正常组织中的表达水平。结果 SCAMP2在CRC组织中低表达,在癌旁正常组织中高表达。CRC组织及癌旁正常组织中SCAMP2的表达水平差异具有统计学意义(t=5.042,P<0.05)。在CRC组织中SCAMP2表达水平与肿瘤大小、微卫星不稳定性(MSI)有关(χ^(2)=6.953、4.923,P<0.05)。结论 SCAMP2在CRC组织中低表达,可能与CRC的发生发展密切相关,SCAMP2低表达的CRC患者肿瘤体积较大,提示SCAMP2可作为CRC潜在的治疗靶点。Objective To investigate the expression and significance of secretory carrier membrane protein 2(SCAMP2)in colorectal cancer(CRC).Methods Paraffin tissue samples and clinicopathological data were collected from 309 patients with primary CRC who were treated in The Affiliated Hospital of Qingdao University from January 2014 to August 2016,and immunohistochemistry was used to measure the expression level of SCAMP2 in CRC tissue and adjacent tissue.Results SCAMP2 showed a low expression level in CRC tissue and a high expression level in adjacent tissue,and there was a significant difference in the expression level of SCAMP2 between CRC tissue and adjacent tissue(t=5.042,P<0.05).The expression level of SCAMP2 in CRC tissue was associated with tumor size and microsatellite instability(χ^(2)=6.953,4.923,P<0.05).Conclusion The low expression of SCAMP2 in CRC tissue may be closely associated with the development and progression of CRC,and CRC patients with low expression of SCAMP2 tend to have a significant increase in tumor volume,suggesting that SCAMP2 can be used as a potential therapeutic target for CRC.

关 键 词：结直肠肿瘤 载体蛋白质类 膜蛋白质类 微卫星不稳定性 肿瘤负荷 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]