中老年居民膳食模式与高尿酸血症的关系研究  

ASSOCIATION BETWEEN DIETARY PATTERN AND HYPERURICEMIA IN MIDDLE-AGED AND ELDERLY RESIDENTS

作　　者：林津泽 刘金海 王亮亮 季丹 罗国强 王治 崔静[5] 孙健平[5] LIN Jinze;LIU Jinhai;WANG Liangliang;JI Dan;LUO Guoqiang;WANG Zhi;CUI Jing;SUN Jianping(School of Public Health,Weifang Medical College,Weifang 261000,China)

机构地区：[1]潍坊医学院公共卫生学院,山东潍坊261000 [2]青岛城阳古镇正骨医院手足外科 [3]青岛市第六人民医院 [4]青岛大学公共卫生学院 [5]青岛市疾病预防控制中心

出　　处：《精准医学杂志》2023年第2期154-158,共5页Journal of Precision Medicine

基　　金：世界糖尿病基金(WDF05-108);青岛糖尿病预防项目(WDF07-308);青岛市科技局立项项目(19-6-1-5-nsh)。

摘　　要：目的探讨中老年居民膳食模式与高尿酸血症(hyperuricemia,HUA)的关系。方法于2009年1月-2012年12月采用分层抽样的方法选取青岛地区3349例45~74岁的中老年人群,并对其进行问卷调查(人口学信息、个人疾病史、行为习惯、食物摄入情况等)、体格检查与生化指标检测等;采用因子分析法提取膳食模式,采用非条件Logistic回归分析膳食模式与HUA的关系,采用限制性立方样条模型分析膳食模式因子得分与HUA的剂量-反应关系。结果因子分析得出内脏-禽肉-河鲜模式、蔬果-粮谷-豆类模式、蛋类-畜肉-奶类模式等3种膳食模式。非条件Logistics回归分析显示,在校正年龄、性别、BMI、饮酒、运动、高血压、血脂异常等混杂因素后,内脏-禽肉-河鲜模式T3水平与HUA患病风险呈正相关(OR=1.32,95%CI=1.02~1.70),蔬果-粮谷-豆类模式T3水平与HUA患病风险呈负相关(OR=0.74,95%CI=0.58~0.95),蛋类-畜肉-奶类模式与HUA患病风险无关。限制性立方样条模型显示,内脏-禽肉-河鲜模式和蛋类-畜肉-奶类模式与HUA患病率呈线性的剂量反应关系,蔬果-粮谷-豆类模式与HUA患病率呈现非线性的剂量反应关系。在蔬果-粮谷-豆类模式得分为0.833时,HUA患病风险最低(OR=0.72,95%CI=0.56~0.92)。结论内脏-禽肉-河鲜模式与中老年人群HUA患病风险呈正相关,而蔬果-粮谷-豆类模式与中老年人群HUA的患病风险呈负相关,中老年人群尤其是HUA患者应合理均衡膳食。Objective To investigate the association between dietary pattern and hyperuricemia(HUA)in middle-aged and elderly residents.Methods From January 2009 to December 2012,the stratified sampling method was used to select 3349 middle-aged and elderly residents aged 45-74 years in Qingdao,China,and a questionnaire survey(demographic information,personal medical history,behavioral habits,and food intake),physical examination,and biochemical tests were performed for all residents.The factor analysis was used to identify dietary pattern,the non-conditional logistic regression analysis was used to investigate the association between dietary pattern and HUA,and the restricted cubic spline model was used to analyze the dose-response relationship between dietary pattern factor scores and HUA.Results The factor analysis obtained three dietary patterns,i.e.,Offal-Poultry-Aquatic pattern,Fruits and Vegetables-Grain-Beans pattern,and Eggs-Meat-Dairy pattern.The non-conditional Logistic regression analysis showed that after adjustment for the confounding factors including age,sex,body mass index,drinking,exercise,hypertension,and dyslipidemia;the highest tertile of the Offal-Poultry-Aquatic pattern was positively associated with the risk of HUA(OR=1.32,95%CI=1.02-1.70),and the highest tertile of the Fruits and Vegetables-Grain-Beans pattern was ne-gatively associated with the risk of HUA(OR=0.74,95%CI=0.58-0.95),while the Eggs-Meat-Dairy pattern was not significantly associated with the risk of HUA.The restricted cubic spline model showed a linear dose-response relationship between Offal-Poultry-Aquatic pattern/Eggs-Meat-Dairy pattern and the prevalence rate of HUA and a non-linear dose-response relationship between Fruits and Vegetables-Grain-Beans pattern and the prevalence rate of HUA.The lowest risk of HUA was observed when the Fruits and Vegetables-Grain-Beans pattern had a score of 0.833(OR=0.72,95%CI=0.56-0.92).Conclusion The Offal-Poultry-Aquatic pattern is positively associated with the risk of HUA in middle-aged and elde

关 键 词：高尿酸血症 膳食调查 因素分析 统计学 中年人 老年人 

分 类 号：R589.7[医药卫生—内分泌] R589.9[医药卫生—内科学]