睑缘深部清洁联合强脉冲光治疗蠕形螨睑缘炎的临床效果  

CLINICAL EFFICACY OF EYELID MARGIN DEEP CLEANING COMBINED WITH INTENSE PULSED LIGHT IN TREATMENT OF DEMODEX BLEPHARITIS

作　　者：苏梅 苏静静 程丹 林宝涛[2] 郭萍 SU Mei;SU Jingjing;CHENG Dan;LIN Baotao;GUO Ping(Second Clinical College of Medicine,Jinan University,Shenzhen 518000,China)

机构地区：[1]暨南大学第二临床医学院,广东深圳518000 [2]深圳市眼科医院角膜病与眼表疾病科,暨南大学附属深圳眼科医院,深圳市眼病防治研究所

出　　处：《精准医学杂志》2023年第2期172-175,共4页Journal of Precision Medicine

基　　金：深圳市科技计划项目(GJHZ20190821113607205)。

摘　　要：目的探讨睑缘深部清洁联合强脉冲光(IPL)对蠕形螨睑缘炎患者的临床治疗效果。方法选取2021年7月-2022年3月于深圳市眼科医院确诊为蠕形螨睑缘炎的患者60例(120眼),根据治疗方式不同将患者分为睑缘深部清洁组(A组,60眼)及联合IPL组(B组,60眼)。比较每组患者治疗前及治疗2个月后的眼表疾病指数(OSDI)评分、睑缘炎症评分、睑板腺开口评分、睑板腺分泌物评分、睑板腺缺失评分及睑缘蠕形螨计数等指标及其治疗前后差值。结果治疗2个月后,两组患者的OSDI评分、睑缘炎症评分、睑板腺开口评分、睑板腺分泌物评分和蠕形螨计数均较治疗前明显下降(t=6.880~15.959,P<0.05),而睑板腺缺失程度评分较前均无明显差异(P>0.05);两组患者的OSDI评分、睑缘炎症评分、睑板腺开口评分、睑板腺分泌物评分和蠕形螨计数治疗前后差值比较差异具有显著性(t=2.047~5.685,P<0.05),睑板腺缺失程度评分差值比较差异无显著性(P>0.05)。结论睑缘深部清洁联合IPL治疗能够减轻患者眼部不适感,改善睑板腺分泌状况,减少睑缘蠕形螨数量,从而有效治疗蠕形螨睑缘炎。Objective To investigate the clinical efficacy of eyelid margin deep cleaning combined with intense pulsed light(IPL)in the treatment of patients with demodex blepharitis.Methods A total of 60 patients(120 eyes)who were diagnosed with demodex blepharitis in Shenzhen Eye Hospital from July 2021 to March 2022 were enrolled,and according to the treatment modality,they were divided into eyelid margin deep cleaning group(group A with 60 eyes)and eyelid margin deep cleaning+IPL group(group B with 60 eyes).The two groups were compared in terms of Ocular Surface Disease Index(OSDI)score,eyelid inflammation score,meibomian gland opening score,meibomian gland secretion score,meibomian gland loss score,and demodex mite count before treatment and after 2 months of treatment,as well as the changes in these indices after treatment.Results After 2 months of treatment,both groups had significant reductions in OSDI score,eyelid inflammation score,meibomian gland opening score,meibomian gland secretion score,and demodex mite count(t=6.880-15.959,P<0.05),with no significant change in meibomian gland loss score(P>0.05).There were significant differences between the two groups in the changes in OSDI score,eyelid inflammation score,meibomian gland opening score,meibomian gland secretion score,and demodex mite count after treatment(t=2.047-5.685,P<0.05),with no significant difference in the change in meibomian gland loss score(P>0.05).Conclusion Eyelid margin deep cleaning combined with IPL exerts a marked therapeutic effect on demodex blepharitis by alleviating eye discomfort,improving meibomian gland secretion,and reducing the number of demodex mites.

关 键 词：眼睑炎 螨感染 强脉冲光疗法 睑板腺功能障碍 灌洗疗法 

分 类 号：R777.1[医药卫生—眼科]