三七通舒胶囊联合丁苯酞对急性脑梗死患者血液流变学、MBP、MCP-1及ET-1的影响  

Effects of Sanqi Tongshu capsule combined with butylphthalide on hemorheology,MBP,MCP-1 and ET-1 in patients with acute cerebral infarction

作　　者：岳弘伟 杨雪微 余丹华 YUE Hongwei;YANG Xuewei;YU Danhua(Department of Neurology,Yiwu Central Hospital,Yiwu 322000,Zhejiang,China)

机构地区：[1]义乌市中心医院神经内科,浙江义乌322000

出　　处：《中国现代医生》2023年第14期82-85,89,共5页China Modern Doctor

摘　　要：目的探究三七通舒胶囊联合丁苯酞对急性脑梗死患者血液流变学、髓鞘碱性蛋白(myelin basic protein,MBP)、单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)及内皮素-1(endothelin-1,ET-1)的影响。方法选取2021年1月至2022年4月于义乌市中心医院就诊的106例急性脑梗死患者,采用随机数字表法分为对照组(n=53)与观察组(n=53)。两组患者均给予常规对症支持治疗,对照组予以丁苯酞治疗,观察组在对照组基础上联合三七通舒胶囊治疗。观察两组治疗后临床疗效,比较两组治疗前后血液流变学、MBP、MCP-1、ET-1水平,以及美国国立卫生研究院卒中量表(National Institutes of Health stroke scale,NIHSS)、改良Rankin量表(modified Rankin scale,m RS)分数及Barthel指数(Barthel index,BI)。结果治疗后,观察组临床总有效率显著高于对照组(P<0.05);两组纤维蛋白原(fibrinogen,FIB)、血浆黏度(plasma viscosity,PV)、红细胞聚集指数、血细胞比容(hematocrit,HCT)、NIHSS评分、m RS评分、MBP、MCP-1及ET-1水平均较治疗前显著下降(P<0.05),而BI指数较治疗前显著升高(P<0.05)。观察组FIB、PV、红细胞聚集指数、HCT、MBP、MCP-1、ET-1水平及NIHSS评分、m RS评分显著低于对照组(P<0.05),而BI指数高于对照组(P<0.05)。结论三七通舒胶囊联合丁苯酞治疗急性脑梗死,可改善患者血液流变学、促进神经功能恢复、增强其日常生活能力,其作用机制可能与MBP、MCP-1及ET-1紊乱有关。Objective To investigate the effects of Sanqi Tongshu capsule combined with butylphthalide on hemorheology,myelin basic protein(MBP),monocyte chemotactic protein-1(MCP-1)and endothelin-1(ET-1)in patients with acute cerebral infarction.Methods A total of 106 patients with acute cerebral infarction attending Yiwu Central Hospital from January 2021 to April 2022 were selected and divided into control group(n=53)and observation group(n=53)according to the random number table method.Patients in both groups were given conventional symptomatic support treatment,the control group was treated with butylphthalide,and the observation group was treated with Sanqi Tongshu capsule on top of the control group.The clinical efficacy of the two groups was observed,and the levels of blood rheology,MBP,MCP-1,ET-1,National Institutes of Health stroke scale(NIHSS)scores,modified Rankin scale(mRS)scores,and Barthel index(BI)were compared between the two groups before and after treatment.Results After treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of fibrinogen(FIB),plasma viscosity(PV),red blood cell aggregation index,hematocrit(HCT),NIHSS scores,mRS scores,MBP,MCP-1 and ET-1 in the two groups were significantly lower than those before treatment(P<0.05),while BI was significantly higher than that before treatment(P<0.05);the levels of FIB,PV,red blood cell aggregation index HCT,NIHSS scores,mRS socres,MBP,MCP-1 and ET-1 in the observation group were significantly lower than those in the control group(P<0.05),while BI index was higher than the control group.(P<0.05).Conclusions Sanqi Tongshu capsule combined with butylphthalide in the treatment of acute cerebral infarction can improve patients’blood rheology,promote neurological recovery and enhance their daily living ability,and its mechanism of action may be related to MBP,MCP-1 and ET-1 disorders.

关 键 词：三七通舒胶囊 丁苯酞 急性脑梗死 血液流变学 髓鞘碱性蛋白 单核细胞趋化蛋白-1 内皮素-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]