基于数据挖掘探讨吕文良教授治疗自身免疫性肝病的用药规律  

Medication rule of Professor LüWenliang in treating autoimmune liver disease based on data mining

作　　者：姚子昂 赵鑫[1] 吕文良[1] 张丽丽 强睿 YAO Ziang;ZHAO Xin;LYU Wenliang;ZHANG Lili;QIANG Rui(Department of Infectious Diseases,Guang’anmen Hospital,China Academy of Chinese Medicinal Sciences,Beijing100053,China)

机构地区：[1]中国中医科学院广安门医院感染疾病科,北京100053

出　　处：《中国医药导报》2023年第15期4-11,共8页China Medical Herald

基　　金：国家重点研发计划中医药现代化研究重点专项(2018YFC1705700);中国中医科学院科技创新工程重点项目(Cl2021A00801、Cl2021A00802)。

摘　　要：目的通过整理吕文良教授治疗自身免疫性肝病的病案,基于数据挖掘探讨吕文良教授治疗自身免疫性肝病的用药规律和学术思想。方法通过中国中医科学院广安门医院信息中心调取吕文良教授于2019年1月1日至2022年1月1日的门诊病历信息,筛选其中西医诊断为自身免疫性肝病的患者,提取中西医诊断、处方用药等信息,利用Excel 2016将处方信息规范化整理成数据库,使用中医传承计算平台V 3.0和R语言(R 4.2.1)对处方进行药物使用频数、功效、四气、五味及归经的分布规律统计,再进行组方规律和聚类分析。结果通过纳排标准筛选整理出658首方剂,158味中药;分析用药规律可知所用中药的四气以温性、寒性、平性为主;五味以苦味、甘味、辛味为主;归经以肝经、脾经、肺经、胃经四经为主;药物功效以补虚类、清热类、消食类为主。在药物使用频数上,最高频使用5味药物是黄芪、白芍、山楂、黄芩、黄连。通过关联规则分析得出,使用频数最高的对药为黄芪-白芍;使用频数最高的角药为黄芪-白芍-山楂。通过K均值聚类算法可将处方分为4个聚类,并得出核心处方药物。结论吕文良教授治疗自身免疫性肝病的处方具有鲜明的用药规律,治疗上以“益气活血、柔肝健脾、清热祛湿”为原则,用药上注重气血同调、寒温相配、气机升降、消补兼施;为现今中医临床诊治自身免疫性肝病提供了辨治思路和遣方用药的参考。Objective To explore the medication rules and academic thoughts of Professor LüWenliang’s treatment of autoimmune liver disease,through sorting out the medical records of Professor LüWenliang’s treatment of autoimmune liver disease,based on the data mining.Methods The outpatient medical record information of Professor LüWenliang from January 1,2019 to January 1,2022 was retrieved through the Information Center of Guang’anmen Hospital,China Academy of Chinese Medical Sciences,the patients diagnosed with autoimmune liver disease by Western medicine were screened,and the information of diagnosis and prescription of traditional Chinese and western medicine was extracted.Excel 2016 was used to standardize the prescription information into a database.Traditional Chinese medicine inheritance computing platform V 3.0 and R language(R 4.2.1)were used to calculate the distribution rules of drug use frequency,efficacy,four qi,five flavor,and meridian conversion,then the rule of formulation and cluster analysis were carried out.Results A total of 658 prescriptions and 158 traditional Chinese medicines were sorted out by inclusion and exclusion standard screening.The analysis of the rule of drug use showed that the four qi of the traditional Chinese medicine were mainly warm,cold,and flat;the five flavors are mainly bitter,sweet,and hot,the main channels are liver,spleen,lung,and stomach.The drug effect is mainly to supplement deficiency class,clearing heat class,and digestion class.In terms of the frequency of drug use,the top five drugs were Astragalus,Paeony,Hawthorn,Scutellaria,and Coptis chinensis.Association rule analysis showed that Astragalus-Paeony was the most frequently used antidrug.The prescriptions can be divided into four clusters by K-means clustering algorithm,and the core prescription drugs can be obtained.Conclusion Professor LüWenliang’s prescription for the treatment of autoimmune liver disease has distinct medication rules.The treatment is based on the principle of“invigorating qi and blood

关 键 词：自身免疫性肝病 吕文良 中医传承计算平台V3.0 R语言 处方挖掘 用药规律 

分 类 号：R730.5[医药卫生—肿瘤]