盐诱导激酶与神经精神系统疾病相关性的研究进展  

Research progress on the correlation between salt-inducible kinase and neuropsychiatric diseases

作　　者：李溪 张彦可 LI Xi;ZHANG Yanke(Clinical Medicine School of Jining Medical College,Jining,Shandong 272000,China;不详)

机构地区：[1]济宁医学院临床医学院,山东济宁272000 [2]济宁医学院附属医院神经内科,山东济宁272000

出　　处：《中国临床研究》2023年第5期730-733,共4页Chinese Journal of Clinical Research

基　　金：国家自然科学基金(81901324);济宁市重点研发计划项目(2021YXNS057)。

摘　　要：盐诱导激酶是一种丝氨酸/苏氨酸蛋白激酶,在能量代谢、细胞信号转导、细胞周期、肿瘤、黑素原生成等诸多方面发挥重要作用。目前大量研究表明,抑郁症、睡眠障碍、癫痫、脑卒中等疾病的发生发展与盐诱导激酶密切相关。本文将重点阐述盐诱导激酶与神经精神系统疾病相关性的研究进展。Salt-inducible kinase(SIK)is a serine/threonine protein kinase.It has been confirmed that SIK plays an important role in energy metabolism,cell signal transduction,cell cycle,tumor,melanogenesis and many other aspects.At present,a large number of studies have shown that the occurrence and development of depression,sleep disorders,epilepsy,stroke and other diseases are closely related to SIK.This article will focus on the research progress of the correlation between SIK and neuropsychiatric diseases.

关 键 词：盐诱导激酶 昼夜节律 抑郁症 癫痫 脑卒中 

分 类 号：R74[医药卫生—神经病学与精神病学]