原发睾丸弥漫大B细胞淋巴瘤临床特征、治疗及预后分析  

Clinical characteristics,treatment and prognosis of primary testicular diffuse large B-cell lymphoma

作　　者：张静 刘长虎[2] 杜尚亭 赵银冰 苗倩倩 詹文华[2] ZHANG Jing;LIU Changhu;DU Shangting;ZHAO Yinbing;MIAO Qianqian;ZHAN Wenhua(Graduate School of Ningxia Medical University,Ningxia Yinchuan 750004,China;Department of Radiotherapy,General Hospital of Ningxia Medical University,Ningxia Yinchuan 750004,China)

机构地区：[1]宁夏医科大学研究生学院,宁夏银川750004 [2]宁夏医科大学总医院放疗科,宁夏银川750004

出　　处：《现代肿瘤医学》2023年第12期2289-2292,共4页Journal of Modern Oncology

基　　金：宁夏回族自治区重点研发计划项目(编号:2022BEG03080)。

摘　　要：目的:探讨原发睾丸弥漫大B细胞淋巴瘤(primary testicular diffuse large B-cell lymphoma,PT-DLBCL)的临床特征、治疗、疗效及预后。方法:收集宁夏医科大学总医院2012年04月至2022年04月收治的30例PT-DLBCL患者临床资料进行回顾性分析。结果:30例患者1、3、5年总生存率分别为93.1%、76.8%、66.3%;1、3、5年无进展生存率分别为79.7%、62.6%、62.6%。单因素分析显示:年龄、IPI评分、LDH水平、Hb水平、综合治疗模式、近期疗效与患者总生存均有关(P<0.05);年龄、IPI评分、Hb水平、综合治疗模式、是否联合利妥昔单抗、近期疗效与患者无进展生存均有关(P<0.05)。多因素分析显示:是否联合利妥昔单抗是影响PT-DLBCL患者无进展生存的独立预后因素。结论:PT-DLBCL属罕见的侵袭性结外淋巴瘤,复发率较高,是否联合利妥昔单抗是影响PT-DLBCL患者无进展生存的独立预后因素。Objective:To investigate the clinical features,treatment and prognosis of primary testicular diffuse large B-cell lymphoma(PT-DLBCL).Methods:The clinical data of 30 PT-DLBCL patients treated in General Hospital of Ningxia Medical University from April 2012 to April 2022 were retrospectively analyzed.Results:The 1,3,5-year overall survival rates were 93.1%,76.8%and 66.3%,the 1,3,5-year progression-free survival rates were 79.7%,62.6%and 62.6%.Univariate analysis showed that age,IPI score,LDH level,Hb level,comprehensive treatment,therapeutic effcet were prognostic factors for overall survival(P<0.05).Age,IPI score,Hb level,the using of rituximab,comprehensive treatment and therapeutic effcet were prognostic factors for progression-free survival(P<0.05).Multivariate analysis showed that the using of rituximab were independent prognostic factors for progression-free survival.Conclusion:PT-DLBCL is a rare and aggressive extranodal lymphoma with a high recurrence rate.The using of rituximab was independent prognostic factors for progression-free survival.

关 键 词：原发睾丸淋巴瘤 弥漫大B细胞淋巴瘤 临床特征 预后 

分 类 号：R733.4[医药卫生—肿瘤]