基于移动医疗APP及微信群管理的综合干预对急性髓细胞白血病患者骨髓移植术后免疫功能恢复及感染风险的影响  

Influence of comprehensive intervention based on mobile medical APP and WeChat group management on immune recovery and infection risk of patients with acute myeloid leukemia after bone marrow transplantation

作　　者：王淑琼 刘宁宁 任盼盼 Wang Shuqiong;Liu Ningning;Ren Panpan(Department of Hematology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院血液科,洛阳471000

出　　处：《国际移植与血液净化杂志》2023年第1期5-9,共5页International Journal of Transplantation and Hemopurification

摘　　要：目的探讨基于移动医疗APP及微信群管理的综合干预对急性髓细胞白血病(AML)骨髓移植术后患者免疫恢复水平及感染风险的影响。方法严格执行纳、排标准后,前瞻性选取我院血液科2020年2月至2022年2月期间收治的103例AML骨髓移植术后患者作为研究对象,按照数字表法将所有患者随机分为两组,常规组51例给予常规护理,联合组52例在常规组的基础上联合基于移动医疗APP及微信群管理的综合干预。观察两组患者免疫功能、负性情绪、生活质量以及术后感染发生率。结果干预前两组患者CD_(3)^(+)T淋巴细胞、CD_(4)^(+)T淋巴细胞、CD_(8)^(+)T淋巴细胞以及CD_(4)^(+)/CD_(8)^(+)T淋巴细胞对比差异无统计学意义(P>0.05),干预结束后两组患者CD_(3)^(+)T淋巴细胞、CD_(4)^(+)T淋巴细胞、CD_(4)^(+)/CD_(8)^(+)T淋巴细胞均上升且联合组高于常规组,两组CD_(8)^(+)T淋巴细胞均下降且联合组低于常规组(P<0.05)。干预前两组焦虑自评量表(SAS)和抑郁自评量表(SDS)评分对比差异无统计学意义(P>0.05),干预6个月后两组SAS和SDS评分均降低且联合组低于常规组(P<0.05)。干预前两组生活质量各维度评分对比差异无统计学意义(P>0.05),干预6个月后两组生活质量各维度评分均上升且联合组高于常规组(P<0.05)。干预期间,联合组术后各感染发生率均低于常规组(P<0.05)。结论将基于移动医疗APP及微信群管理的综合干预用于AML骨髓移植术后患者,可调节机体免疫功能,减轻负性情绪的影响,提高生活质量,降低术后感染发生的风险。Objective To explore the influence of comprehensive intervention based on mobile medical APP and WeChat group management on the immune recovery level and infection risk of patients with acute myeloid leukemia(AML)after bone marrow transplantation.Methods After strict implementation of the inclusion and exclusion criteria,103 patients with AML after bone marrow transplantation admitted in our hospital from February 2020 to February 2022 were prospectively selected as the research objects.All the patients were divided into two groups according to the random number table method.51 patients in the conventional group were given routine care,and 52 patients in the combined group were given comprehensive intervention based on mobile medical apps and WeChat group management on the basis of the conventional group.The immune function,negative emotions,quality of life and the incidence of postoperative infection were observed.Results There was no significant difference in CD_(3)^(+),CD_(4)^(+),CD_(8)^(+)and CD_(4)^(+)/CD_(8)^(+)T cells between the two groups before the intervention(P>0.05).After the intervention,the levels of CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+)T cells in the two groups increased,and those in the combined group were higher than those in the conventional group,while those in the two groups decreased,and those in the combined group were lower than those in the conventional group(P<0.05).There was no significant difference in SAS and SDS scores between the two groups before intervention(P>0.05).After 6 months of intervention,SAS and SDS scores in both groups decreased,and those in the combined group were lower than those in the conventional group(P<0.05).There was no significant difference between the two groups in the scores of each dimension of quality of life before the intervention(P>0.05).After 6 months of intervention,the scores of each dimension of quality of life in the two groups increased and the combined group was higher than the conventional group(P<0.05).During the intervention period,the i

关 键 词：急性髓细胞白血病 骨髓移植 免疫功能 负性情绪 感染 

分 类 号：R733.71[医药卫生—肿瘤]