理气通便方联合乳果糖口服液治疗小儿慢性传输性便秘临床研究  

Clinical Study on Liqi Tongbian Prescription Combined with Lactulose Oral Solution for Chronic Transmission Constipation in Children

作　　者：梁飞 范晖 刘歌 张晓玲 徐嘉辉[3] 周俊亮 赖东兰[1] LIANG Fei;FAN Hui;LIU Ge;ZHANG Xiaoling;XU Jiahui;ZHOU Junliang;LAI Donlan

机构地区：[1]广州中医药大学第一附属医院儿科,广东广州510405 [2]广东祈福医院儿科,广东广州511496 [3]广东省第二中医院,广东广州510000 [4]广州中医药大学附属南海妇产儿童医院,广东佛山528000

出　　处：《新中医》2023年第9期144-147,共4页New Chinese Medicine

基　　金：广东省中医药局面上科研项目(20191415);广东省科技厅科研项目(2017ZC0340)。

摘　　要：目的:观察理气通便方联合乳果糖口服液治疗小儿慢性传输性便秘的临床疗效。方法:选取小儿慢性传输性便秘患者96例作为研究对象,按随机数字表法分为对照组和观察组各48例。对照组给予乳果糖口服液治疗,观察组在对照组基础上增加理气通便方治疗。评价2组临床疗效,比较2组治疗前后血清P物质(SP)、一氧化氮(NO)以及生长抑素(SS)水平及临床症状评分,统计2组不良反应发生率。结果:观察组总有效率为100%,高于对照组87.50%,差异有统计学意义(P<0.05)。治疗后,2组SP水平较治疗前升高,NO及SS水平较治疗前降低(P<0.05);且观察组SP水平高于对照组,NO及SS水平低于对照组(P<0.05)。治疗后,2组各项临床症状评分低于治疗前(P<0.05),且观察组各项临床症状评分低于对照组(P<0.05)。观察组不良发生率为4.16%,低于对照组20.83%,差异有统计学意义(P<0.05)。结论:理气通便方联合乳果糖口服液治疗小儿慢性传输性便秘可以提高临床疗效,改善血清P物质水平,促进恢复肠道动力,改善临床症状,降低不良反应发生率。Objective:To observe the clinical effect of Liqi Tongbian Prescription combined with Oral Solution for chronic transmission constipation in children.Methods:A total of 96 cases of children with chronic transmission constipation were selected as the study subjects and divided into the control group and the observation group according to the random number table method,with 48 cases in each group.The control group was treated with Lactulose Oral Solution,and the observation group was additionally treated with Liqi Tongbian Prescription based on the treatment of the control group.The clinical effects were evaluated in the two groups.Before and after treatment,the levels of substance P(SP),nitric oxide(NO),and somatostatin(SS)in serum,and the clinical symptom scores were compared between the two groups.The incidence of adverse reactions were counted in the two groups.Results:The total effective rate was 100%in the observation group,higher than that of 87.50%in the control group,the difference being significant(P<0.05).After treatment,the SP levels in the two groups were increased when compared with those before treatment,and the levels of NO and SS were decreased when compared with those before treatment(P<0.05);the SP level in the observation group was higher than that in the control group,and the levels of NO and SS were lower than those in the control group(P<0.05).After treatment,each clinical symptom score in the two groups was lower than that before treatment(P<0.05),and each clinical symptom score in the observation group was lower than that in the control group(P<0.05).The incidence of adverse reactions was 4.16%in the observation group,lower than that of 20.83%in the control group,the difference being significant(P<0.05).Conclusion:Liqi Tongbian Prescription combined with Lactulose Oral Solution can improve the clinical effect,the level of substance P in serum,and clinical symptoms,promote the recovery of intestinal motility,and reduce the incidence of adverse reactions in the treatment of chronic transmissio

关 键 词：慢性传输性便秘 小儿 理气通便方 乳果糖口服液 血清P物质 一氧化氮 生长抑素 临床症状评分 

分 类 号：R574.62[医药卫生—消化系统]