消岩汤联合卡培他滨和贝伐珠单抗在结直肠癌维持治疗中的临床研究  

A clinical study of Xiaoyan decoction combined with capecitabine and bevacizumab for the maintenance treatment of colorectal cancer

作　　者：孔凡铭[1] 王娜 谢红霞 赵璐 张豆 张晶 张丽丽[1] 陈立伟[1] 贾英杰[1] Fanming Kong;Na Wang;Hongxia Xie;Lu Zhao;Dou Zhang;Jing Zhang;Lii Zhang;Liwei Chen;Yingjie Jia(Department of Oncology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院肿瘤科,国家中医针灸临床医学研究中心,天津市300193

出　　处：《中国肿瘤临床》2023年第10期519-525,共7页Chinese Journal of Clinical Oncology

基　　金：国家中医药管理局第七批全国老中医药专家学术经验继承项目;国家重点研发计划项目(编号:2018YFC1707400);天津市卫生计生行业高层次人才选拔培养工程项目资助。

摘　　要：目的:探讨消岩汤联合卡培他滨和贝伐珠单抗在结直肠癌(colorectal cancer,CRC)维持治疗中的疗效和安全性。方法:回顾性选取2016年1月至2021年12月于天津中医药大学第一附属医院接受一线标准化疗后进入维持治疗阶段的晚期CRC患者120例,分为治疗组(消岩汤联合卡培他滨和贝伐珠单抗维持治疗)60例和对照组(卡培他滨和贝伐珠单抗维持治疗)60例。比较两组间的无进展生存期(progression-free survival,PFS),总生存期(overall survival,OS)和安全性。结果:两组患者在基线特征方面差异无统计学意义,治疗组显著延长了CRC患者的PFS(10.9个月vs.9.2个月,P=0.03),但OS未见显著获益(21.2个月vs.19.4个月,P=0.87)。消岩汤可改善患者神疲乏力(P=0.01)、恶心呕吐(P=0.01)、腹胀(P=0.02)的症状,且能减少恶心呕吐(P=0.04)及腹泻(P=0.02)的不良反应。结论:消岩汤联合卡培他滨和贝伐珠单抗维持治疗可显著提高晚期CRC患者的PFS,减轻胃肠道系统不良反应且安全性良好。Objective:To investigated the efficacy and safety of Xiaoyan decoction combined with capecitabine and bevacizumab for the maintenance treatment in patients with colorectal cancer(CRC).Methods:At the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,a retrospective analysis was conducted for 120 advanced CRC patients who had completed first-line standard chemotherapy and entered maintenance therapy from January 2016 to December 2021.The treatment group(n=60)was treated with Xiaoyan decoction plus capecitabine and bevacizumab,whereas the control group(n=60)was treated with capecitabine and bevacizumab.Progression-free survival(PFS),overall survival(OS),and safety were evaluated.Results:No significant difference in baseline characteristics was observed between the two groups.The treatment group experienced significantly prolonged PFS(10.9 months vs.9.2 months,P=0.03),but no significant benefit was seen in OS(21.2 months vs.19.4 months,P=0.87).Xiaoyan decoction was able to improve the symptoms of fatigue(P=0.01),vomiting(P=0.01),and abdominal distension(P=0.02)and reduce the severity of the adverse reactions of vomiting(P=0.04)and diarrhea(P=0.02).Conclusions:Xiaoyan decoction combined with capecitabine and bevacizumab can significantly improve PFS in advanced CRC patients,reduce gastrointestinal adverse reactions,and provide good safety.

关 键 词：消岩汤 维持治疗 结直肠癌 中医药 

分 类 号：R735.34[医药卫生—肿瘤]