快速眼动期睡眠影响恐惧记忆的研究进展  

Research progress on the influence of REM sleep on fear memory

作　　者：邸天琪 孟适秋[1] 刘王玥 郑恩雨 孙艳[1] 时杰[1] DI Tian-qi;MENG Shi-qiu;LIU Wang-yue;ZHENG En-yu;SUN Yan;SHI Jie(National Institute on Drug Dependence,Peking University,Beijing Key Laboratory of Drug Dependence Research,Beijing 100191,China)

机构地区：[1]北京大学中国药物依赖性研究所,药物依赖性研究北京市重点实验室,北京100191

出　　处：《中国药物依赖性杂志》2023年第2期87-92,共6页Chinese Journal of Drug Dependence

基　　金：科技部科技创新2030-“脑科学与类脑研究”重大项目(2021ZD0202100);国家自然科学基金委重点项目(82130040);国家自然科学基金委基础科学中心项目(82288101)。

摘　　要：恐惧是对某些特定环境刺激或经历的强烈情绪反应,是一种适应性的生理心理活动状态,具有重要的生理学和社会学意义,但恐惧记忆的异常表达会导致创伤后应激障碍等多种精神疾病。睡眠对情绪性记忆的加工处理具有重要作用,在巩固积极情绪的同时抑制恐惧等消极情绪,且主要发生在快速眼动(rapid eye movement,REM)睡眠期。大量研究证实REM睡眠参与并调控恐惧记忆的维持和发展,然而缺乏系统性的文献综述。本文综述了REM睡眠在恐惧记忆习得、巩固、消退、泛化等不同阶段中作用的研究进展,为促进REM睡眠对恐惧记忆的影响及其神经机制的深入研究提供了支持。Fear memory is a powerful emotional response to certain environmental stimuli or experiences and serves as an effective psychological defense mechanism with significant physiological and social significance.However,aberrant expression of fear may contribute to post-traumatic stress disorder and other mental disorders.Sleep plays a crucial role in the processing of emotional memory,serving to consolidate positive emotional memory while suppressing negative emotions such as fear,and this process primarily occurs during rapid eye movement(REM)sleep.A growing body of literature suggests that REM sleep plays a crucial role in regulating the occurrence and development of fear memory,including its acquisition,consolidation,extinction,and generalization.This paper provides a comprehensive review of current research on the influence of REM sleep on fear memories and neural mechanisms,examining both normal physiological function and abnormal states of disease.The aim is to gain a better understanding of the role of REM sleep in fear memories,which can provide new perspectives and potential targets for future research.

关 键 词：快速眼动睡眠 恐惧记忆习得 恐惧记忆巩固 恐惧记忆消退 恐惧记忆泛化 

分 类 号：R749[医药卫生—神经病学与精神病学]