外泌体miRNAs在甲基苯丙胺成瘾中的作用及作为其生物标志物的研究进展  

Research progress on the role of exosomal miRNAs and the possibility as biomarkers in methamphetamine addiction

作　　者：陈晓雨 楼忠泽[2] 洪青晓 王兰兰 刘惠芬[3] 阮列敏[2] CHEN Xiao-yu;LOU Zhong-ze;HONG Qing-xiao;WANG Lan-lan;LIU Hui-fen;RUAN Lie-min(School of Medicine,Ningbo University,Ningbo 315211,Zhejiang,China;Department of Psychosomatic Medicine,Ningbo First Hospital,Ningbo 315010,Zhejiang,China;Ningbo Kangning Hospital,Ningbo Institute of Microcirculation and Henbane,Key Laboratory of Addiction Research of Zhejiang Province,Ningbo 315201,Zhejiang,China)

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市第一医院,浙江宁波315010 [3]宁波市康宁医院,宁波市微循环与莨菪类药研究所,浙江省戒毒研究重点实验室,浙江宁波315201

出　　处：《中国药物依赖性杂志》2023年第2期93-97,103,共6页Chinese Journal of Drug Dependence

基　　金：浙江省基础公益研究项目(LGF22G30010);浙江省卫生健康科技计划项目(2021KY1065);宁波市自然科学基金项目(2017C510010)。

摘　　要：甲基苯丙胺成瘾作为一种慢性、复发性脑病,通常涉及与用药相关的奖赏与动机、学习与记忆、决策与执行等一系列中枢高级功能的异常,导致机体发生急、慢性神经毒性,认知功能损害,人格行为改变以及强迫性觅药用药行为等。然而,甲基苯丙胺成瘾的神经生物学机制尚未被完全阐明,目前仍缺乏有效的干预和治疗措施。近年来,外泌体在甲基苯丙胺成瘾中的研究越来越受到关注,外泌体miRNAs被认为是甲基苯丙胺成瘾生物标志物的重要来源,这为甲基苯丙胺成瘾早期诊断和治疗提供了新的思路与应用前景。本文就外泌体miRNAs在甲基苯丙胺成瘾中的最新研究进展进行综述。Methamphetamine addiction is a chronic relapsing brain disorder that involves a range of abnormalities such as reward and motivation,learning and memory,decision-making and executive and central cognitive-control processes,resulting in acute and chronic neurotoxicity,cognitive impairments,personality and behavioural changes and compulsive drug-seeking behaviour.However,the neurobiological mechanisms underlying methamphetamine addiction and its pathogenesis have not been fully elucidated,and there are still no effective interventions or treatments available,and the therapeutic targets remain unclear.Exosomes are lipid bilayered vesicles carrying biological information molecules including lipids,proteins,DNA and microRNAs,which mediate intercellular information transfer and regulate the expression of related signalling pathways.Currently,there is a growing interest in the role of exosomes in methamphetamine addiction,offering new prospects for the early diagnosis and treatment of methamphetamine addiction.In this paper,we review the latest research progress on exosomal miRNAs in methamphetamine addiction.

关 键 词：甲基苯丙胺 药物成瘾 外泌体 MIRNAS 生物标志物 

分 类 号：R749[医药卫生—神经病学与精神病学]