肝细胞癌合并门静脉癌栓形成机制的研究进展  

Research progress on the formation mechanism of hepatocellular carcinoma with portal vein tumor thrombus

作　　者：王雯 李玮 齐梦剑 苏晓霞 石大林 庞明泉[1] 樊海宁[1] 任利[1] 卢倩 王海久[1] 王志鑫[1] Wang Wen;Li Wei;Qi Mengjian;Su Xiaoxia;Shi Dalin;Pang Mingquan;Fan Haining;Ren Li;Lu Qian;Wang Haijiu;Wang Zhixin(Department of Hepatobiliary and Pancreatic Surgery,Qinghai University Affiliated Hospital,Qinghai Provincial Key Laboratory of Hydatid Disease Research,Xining 810001,China;Department of Hepatobiliary and Pancreatic Surgery,Changgung Hospital of Tsinghua University,Beijing 102218,China)

机构地区：[1]青海大学附属医院肝胆胰外科,青海省包虫病研究重点实验室,西宁810001 [2]清华大学长庚医院肝胆胰外科,北京102218

出　　处：《中华肝胆外科杂志》2023年第4期305-308,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(82160466);青海省科技厅项目(2019-SF-131)。

摘　　要：肝细胞癌是临床中常见的恶性肿瘤,门静脉癌栓(PVTT)是影响肝细胞癌预后的重要因素之一。PVTT肿瘤学特性较强,极易发生肝外转移,并发门静脉高压,导致消化道出血或肝衰竭,引起死亡。本文通过综述肝细胞癌合并PVTT的局部解剖学、血流动力学、分子生物学及肿瘤微环境方面的形成机制,为临床治疗提供参考。Hepatocellular carcinoma is a common malignant disease in clinical practice,and portal vein tumor thrombosis(PVTT)is one of the important factors affecting the prognosis of hepatocellular carcinoma.PVTT has strong oncologic characteristics and is highly susceptible to extrahepatic metastasis,complicating portal hypertension,leading to gastrointestinal bleeding or liver failure and causing death.In this paper,we review the formation mechanism of hepatocellular carcinoma combined with PVTT in terms of local anatomy,hemodynamics,molecular biology and tumor microenvironment to provide effective reference for clinical treatment.

关 键 词：癌 肝细胞 门静脉癌栓 形成机制 

分 类 号：R735.7[医药卫生—肿瘤]