膳食炎症指数与反流性食管炎的相关性研究  

Study on the correlation between dietary inflammatory index and reflux esophagitis

作　　者：翟蕾蕾 崔旻[1] 刘苓[2] 姚萍[1] Zhai Leilei;Cui Min;Liu Ling;Yao Ping(First Department of Gastroenterology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]新疆医科大学第一附属医院消化一科,乌鲁木齐830000 [2]四川大学华西医院消化内科,成都610041

出　　处：《中华消化杂志》2023年第2期96-101,共6页Chinese Journal of Digestion

基　　金：四川省区域创新合作项目(2022YFQ0053)。

摘　　要：目的采用膳食炎症指数(DII)评估炎性膳食与反流性食管炎(RE)的相关性,在膳食指导层面为RE的防治提供科学依据。方法招募2021年12月至2022年9月就诊于新疆医科大学第一附属医院的RE患者(RE组)145例,并按年龄和性别1∶1的比例匹配原则,同期选择新疆医科大学第一附属医院健康体检人群145名作为健康对照(健康对照组)。收集2组人群的基线资料,包括体重指数、吸烟史、饮酒史、不良饮食习惯和体力活动强度等。采用半定量饮食频率问卷收集患者的膳食摄入量,并计算总体DII以评估其膳食潜在抗炎或促炎效应。根据健康对照组DII的三分位数(以33.3%和66.7%为界限),将食物的促炎潜力由低到高分为低促炎类(<-0.06)、中间类(-0.06~1.11)和高促炎类(>1.11)。采用logistic回归模型分析DII与RE风险的关联,采用线性趋势检验比较随着DII水平的增加,RE风险OR值的总体变化趋势。采用独立样本t检验、Mann-WhitneyU检验和卡方检验进行统计学分析。结果 RE组体重指数高于健康对照组[(24.11±2.57) kg/m2比(23.38 ±2.60) kg/m2],差异有统计学意义(t=-2.41,P=0.017),RE组吸烟、饮酒、过饱饮食、睡前3 h内进食比例均高于健康对照组[42.8%(62/145)比31.0%(45/145)、31.0%(45/145)比16.6%(24/145)、33.1%(48/145)比17.9%(26/145)、52.4%(76/145)比13.1%(19/145)],差异均有统计学意义(χ^(2)=4.28、8.39、8.78、50.86,P=0.039、=0.004、=0.003、<0.001),而RE组进食夜宵和从事中重度体力活动的比例均低于健康对照组[14.5%(21/145)比24.1%(35/145)、22.8%(33/145)比37.2%(54/145)],差异均有统计学意义(χ^(2)=4.34、7.24,P=0.037、0.007)。RE组DII高于健康对照组[1.05(0.03,1.62)比0.34(-0.61,1.35)],差异有统计学意义(Z=8 661.50,P=0.010)。相比低促炎类饮食,高促炎类饮食的RE风险增加1.30倍(OR=2.30,95%置信区间1.29~4.09,P=0.005)。调整总能量摄入、年龄、性别、民族、体重指数、文化程度、体力�Objective To evaluate the correlation between inflammatory diet and reflux esophagitis(RE)with the dietary inflammatory index(DII),and to provide scientific evidence for the prevention and treatment of RE at the level of dietary guidance.Methods From December 2021 to September 2022,145 RE patients(RE group)who visited the First Affiliated Hospital of Xinjiang Medical University were recruited.During the same period,145 subjects who underwent check-ups at the First Affiliated Hospital of Xinjiang Medical University were selected as the healthy control group,and age and gender were matched according to the ratio of 1 to 1.The baseline data of the 2 groups,including body mass index,the history of smoking and drinking,poor dietary habits,and physical activity intensity were collected.Dietary intake of the patients was assessed by a semi-quantitative food frequency questionnaire,and the overall DII was calculated to evaluate the potential anti-inflammatory or pro-inflammatory effects of diet.According to the tertiles of the DII of the healthy control group(33.3%and 66.7%as the cut-off),dietary inflammatory potential was divided into low(<-0.06),moderate(-0.06 to 1.11)and high pro-inflammatory potential diet(>1.11).Logistic regression model was performed to analyze the correlation between DII and RE risk.Linear trend test was used to compare the overall change trend of RE risk OR value along with the increase of DII.Independent sample t test,Mann-Whitney U test and chi-square test were used for statistical analysis.Results The body mass index of RE group was higher than that of healthy control group((24.11±2.57)kg/m2 vs.(23.38±2.60)kg/m2),and the difference was statistically significant(t=-2.41,P=0.017).The proportions of smoking,drinking,over-eating,and eating within 3 h before bedtime of RE group was higher than those of the healthy control group(42.8%,62/145 vs.31.0%,45/145;31.0%,45/145 vs.16.6%,24/145;33.1%,48/145 vs.17.9%,26/145;52.4%,76/145 vs.13.1%,19/145),and the differences were statistically significant(χ^

关 键 词：膳食炎症指数 反流性食管炎 促炎饮食 抗炎饮食 

分 类 号：R571[医药卫生—消化系统]