^(18)F-FDG PET/CT在上皮性卵巢癌复发诊断价值的Meta分析  

The diagnostic value of^(18)F-FDG PET/CT in epithelial ovarian cancer recurrence:a meta-analysis

作　　者：胡莎莎[1,2] 王晓燕 刘畅[1,2] 杨丽峰[3] HU Shasha;WANG Xiaoyan;LIU Chang;YANG Lifeng(The First Ward of the Department of Gynecology,the First Hospital of Lanzhou University,Lanzhou 730000,P.R.China;Key Laboratory of Gynecological Oncology of Gansu Province,Lanzhou 730000,P.R.China;School of Nursing,Hexi University,Zhangye 734000,P.R.China)

机构地区：[1]兰州大学第一医院妇科一病区,兰州730030 [2]甘肃省妇科肿瘤重点实验室,兰州730030 [3]河西学院护理学院,甘肃张掖734000

出　　处：《中国循证医学杂志》2023年第5期528-533,共6页Chinese Journal of Evidence-based Medicine

基　　金：甘肃省科技计划项目(编号:20YF3FA031);兰州大学第一医院院内基金(编号:2007002002302);河西学院校长青年基金(编号:QN2022011);甘肃省教育厅创新基金项目(2022B-192)。

摘　　要：目的系统评价^(18)F-FDG PET/CT在上皮性卵巢癌治疗后的复发诊断准确性。方法计算机检索PubMed、EMbase、Cochrane Library、Web of Science、CNKI、WanFang Data、VIP和CBM数据库,搜集^(18)F-FDG PET/CT诊断上皮性卵巢癌复发的临床诊断试验,检索时限均从建库至2023年2月。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Meta-Disc 1.4和Stata 15.0软件进行分析。结果共纳入15个研究,包括792例患者。Meta分析结果显示:^(18)F-FDG PET/CT诊断上皮性卵巢癌复发的敏感度、特异度和曲线下面积分别为0.88[95%CI(0.85,0.90)],0.80[95%CI(0.75,0.85)]和0.91。亚组分析结果显示:前瞻性研究与回顾性研究的敏感度一致,但前瞻性研究的特异度高于回顾性研究;研究区域位于亚洲的^(18)F-FDG PET/CT研究在上皮性卵巢癌复发诊断敏感度和特异度高于欧洲/北美洲的研究。结论^(18)F-FDG PET/CT对上皮性卵巢癌复发具有较高的诊断价值。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。Objective To systematically review the diagnostic value of^(18)F-FDG PET/CT in recurrent epithelial ovarian cancer after treatment.Methods The PubMed,EMbase,Cochrane Library,Web of Science,CNKI,WanFang Data,VIP,and CBM databases were electronically searched to collect diagnostic tests of^(18)F-FDG PET/CT for epithelial ovarian cancer from inception to February 2023.Two reviewers independently screened the literature,extracted data,and assessed the risk of bias of the included studies.Meta-analysis was then performed using Meta-Disc 1.4 and Stata 15.0 software.Results A total of 15 studies involving 792 patients were included in this study.The results of meta-analysis showed that the sensitivity,specificity,and area under the curve of^(18)F-FDG PET/CT in the diagnosis of recurrent epithelial ovarian cancer were 0.88(95%CI 0.85 to 0.90),0.80(95%CI 0.75 to 0.85)and 0.91,respectively.The results of the subgroup analysis showed that the sensitivity of the prospective studies was the same as that of the retrospective studies,but the specificity of the prospective studies was higher than that of the retrospective studies.The diagnostic sensitivity and specificity of^(18)F-FDG PET/CT in recurrent epithelial ovarian cancer were higher in Asian studies than in European/North American studies.Conclusion^(18)F-FDG PET/CT has high diagnostic value in recurrent epithelial ovarian cancer.Due to the limited quantity and quality of the included studies,more high-quality studies are needed to verify the above conclusion.

关 键 词：上皮性卵巢癌 复发 ^(18)F-FDG PET/CT 诊断 META分析 

分 类 号：R737.31[医药卫生—肿瘤]