脑小血管病与生长分化因子15的相关研究进展  

Research Progress of Cerebral Small Vascular Disease and Growth Differentiation Factor 15

作　　者：李根洁 王欣[1] 李雨珊 关越馨 冯念苹[1] LI Gen-jie;WANG Xin;LI Yu-shan;GUAN Yue-xin;FENG Nian-ping(Department of Neurology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院神经内科,哈尔滨150081

出　　处：《中国临床神经科学》2023年第2期236-240,F0003,共6页Chinese Journal of Clinical Neurosciences

基　　金：黑龙江省博士后资助项目(编号:LBH-Z16306)。

摘　　要：脑小血管病(CSVD)是临床常见的一种动态变化的全脑功能紊乱性疾病,其具体发病机制未明,具有广泛研究空间。而生长分化因子15(GDF-15)是TGF-β超家族中的一员,其参与多种血管病理生理改变,具有广泛生物学作用,与血脑屏障渗漏、内皮细胞功能障碍、氧化应激、炎症反应、启动相关信号通路等密切相关。文中着重对CSVD可能发病机制与GDF-15的关系进行综述,为CSVD机制研究提供进一步理论支持。Cerebral small vessel disease(CSVD)is a common and dynamic brain dysfunction in clinical practice.The specific pathogenesis of CSVD is not clear.Growth differentiation factor-15(GDF15),a member of the TGF-βsuperfamily,is involved in a variety of vascular pathophysiological changes and has a wide range of biological effects.It is closely related to blood-brain barrier leakage,endothelial cell dysfunction,oxidative stress,inflammatory response,and initiation of related signaling pathways.This review focuses on the possible pathogenesis of CSVD and the relationship with GDF-15 to provide further theoretical support for the mechanism research of CSVD.

关 键 词：脑小血管病 血脑屏障 内皮细胞 生长分化因子15 

分 类 号：R743[医药卫生—神经病学与精神病学]