体细胞克隆动物胎盘发育异常机制研究进展  

Research Progress on Mechanism of Abnormal Placental Development in Somatic Cell Cloned Animals

作　　者：赵晓雨 吴珊珊 徐涵 李丹弈 李光鹏[1] 苏广华 ZHAO Xiao-Yu;WU Shan-Shan;XU Han;LI Dan-Yi;LI Guang-Peng;SU Guang-Hua(State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock(R2BGL),Inner Mongolia University,Hohhot 010070,China)

机构地区：[1]内蒙古大学生命科学学院省部共建草原家畜生殖调控与繁育国家重点实验室,呼和浩特010071

出　　处：《农业生物技术学报》2023年第6期1304-1313,共10页Journal of Agricultural Biotechnology

基　　金：国家自然科学基金地区基金(32060755);内蒙古自治区自然科学基金(2020BS03023);内蒙古自治区科技重大专项(2020ZD0007,2021ZD0009);内蒙古自治区“科技兴蒙”行动重点专项(KJXM2020002-03)。

摘　　要：体细胞克隆动物存在效率低下的问题,其妊娠成功率只有1%~5%。克隆动物胎盘异常是造成妊娠失败的主要原因,具体包括:胎盘过大、胎盘血管生成缺陷、滋养层异常等。现有研究表明,克隆胎盘中蛋白和印记基因异常表达,胎盘正常发育过程中关键调控基因未能建立正确的表观修饰,可能是造成克隆胎盘出现形态异常和功能缺陷的主要原因。本文描述了克隆胎盘中出现的异常现象以及可能存在的调控机制,为后续体细胞核移植动物的效率提升提供帮助。Somatic cloning of animals has the problem of low efficiency,and its pregnancy success rate is only 1%~5%.Abnormal placenta of cloned animals is the main cause of pregnancy failure,including placental oversize,placental angiogenesis defect,trophoblast abnormality and so on.Although the mechanism of these abnormalities is unclear,the existing evidence shows that the abnormal expression of proteins and imprinted genes in the cloned placenta and the failure of key regulatory genes to establish correct apparent modification in the normal development of the placenta may be the main reasons for the morphological abnormalities and functional defects of the cloned placenta.This review describes the abnormal phenomena and possible regulatory mechanisms in cloned animals placentas,which could help us to improve the efficiency of subsequent somatic cell nuclear transfer in animals.

关 键 词：体细胞核移植 克隆 胎盘 印记基因 表观遗传 

分 类 号：S8-0[农业科学—畜牧兽医]