应重视实时震动诱导转化技术在克-雅病临床诊断中的应用  

Application value of real-time quaking-induced conversion technology in clinical diagnosis of Creutzfeldt-Jakob disease

作　　者：贺电 HE Dian(Department of Neurology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学附属医院神经内科,贵阳550004

出　　处：《中国现代神经疾病杂志》2023年第4期271-274,共4页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：科技创新2030-“脑科学与类脑研究”重大项目(项目编号:2021ZD0201801);贵州省卫生健康委员会科学技术基金资助项目(项目编号:gzwkj2021-018)。

摘　　要：克-雅病是一组由朊蛋白错误折叠引起的临床罕见的神经系统变性疾病,是人类朊病毒病的最常见类型。自20世纪70年代朊病毒特征被认识以来,诊断性检测技术取得长足进展,尤以实时震动诱导转化(RT-QuIC)技术最为突出。本文阐述克-雅病发病机制,RT-QuIC技术作用机制及其在克-雅病诊断中的应用现状,以期促进RT-QuIC技术在我国克-雅病领域的应用与发展。Creutzfeldt-Jakob disease(CJD)is a group of clinically rare neurodegenerative diseases caused by misfolding of prion proteins,and is the most common type of human prion diseases.Since the prion characteristics were recognized in the 1970s,the diagnostic detection technology has made great progress,especially the real-time quaking-induced conversion(RT-QuIC).This paper describes the pathogenesis of CJD,the mechanism of action of RT-QuIC and its application in the diagnosis of CJD in order to promote the application and development of RT-QuIC technology in the field of CJD.

关 键 词：克-亚综合征 朊病毒 诊断 综述 

分 类 号：R741[医药卫生—神经病学与精神病学]