肿瘤相关物质评估非小细胞肺癌骨转移的意义  

Significance of tumor associated material in the evaluation of bone metastasis of non-small-cell lung carcinoma

作　　者：张筠[1] 张铁栓[1] 邵润霞[1] 周雨蒙 高崴崴 ZHANG Yun;ZHANG Tieshuan;SHAO Runxia;ZHOU Yumeng;GAO Weiwei(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院呼吸与危重症医学科,河南郑州450014

出　　处：《肿瘤基础与临床》2023年第3期232-236,共5页journal of basic and clinical oncology

摘　　要：目的探讨肿瘤相关物质(TAM)对非小细胞肺癌发生骨转移的评估意义。方法选取2019年4月至2022年6月郑州大学第二附属医院收治的非小细胞肺癌患者110例,根据有无出现骨转移分为骨转移组与非骨转移组,回顾性采集并比较分析患者年龄、性别、病理类型、吸烟状况、血清神经元特异性烯醇化酶(NSE)、血清TAM、血清白蛋白(ALB)、血清钙(Ca)、血清碱性磷酸酶(ALP)、血常规数据。结果骨转移组与非骨转移组病理类型(χ^(2)=4.365,P=0.037)、血清NSE(Z=2.518,P=0.012)、血清TAM(Z=4.142,P<0.001)、血清Ca(Z=3.066,P=0.002)、血清ALP(Z=4.203,P<0.001)、白细胞(WBC)(Z=2.143,P=0.032)、中性粒细胞(NE)(Z=2.461,P=0.014)比较差异均有统计学意义;血清TAM与血清ALP(r=0.220,P=0.021)、WBC(r=0.383,P<0.001)、NE(r=0.401,P<0.001)呈正相关;血清TAM(OR=1.046,95%CI:1.013~1.080,P=0.007)、血清ALP(OR=1.023,95%CI:1.006~1.039,P=0.006)是非小细胞肺癌患者发生骨转移的独立危险因素;血清TAM、ALP评估非小细胞肺癌患者发生骨转移的曲线下面积分别为0.730、0.733,敏感性分别为70%、54%,特异性分别为78.3%、86.7%,最佳临界值分别为97.145 u/mL、105 u/L,两者的敏感性(χ^(2)=1.691,P=0.193)和特异性(χ^(2)=2.652,P=0.103)比较差异均无统计学意义。结论TAM在评估非小细胞肺癌是否发生骨转移方面有较好的临床价值。Objective To investigate the significance of tumor associated material(TAM)in bone metastasis of non-small-cell lung carcinoma.Methods The 110 non-small-cell lung carcinoma patients admitted to the Second Affiliated Hospital of Zhengzhou University from April 2019 to June 2022 were divided into the bone metastasis group and the non-bone metastasis group,age,sex,pathological type,smoking status,neuron specific enolase(NSE),serum TAM,serum calcium(Ca),serum alkaline phosphatase(ALP),serum albumin(ALB),blood routine data were collected and analyzed retrospectively.Results There were significant differences in pathological type(χ^(2)=4.365,P=0.037),serum NSE(Z=2.518,P=0.012),serum TAM(Z=4.142,P<0.001),serum Ca(Z=3.066,P=0.002),serum ALP(Z=4.203,P<0.001),WBC(Z=2.143,P=0.032),NE(Z=2.461,P=0.014)between the bone metastasis group and the non-bone metastasis group.Serum TAM was positively correlated with ALP(r=0.220,P=0.021),WBC(r=0.383,P<0.001),NE(r=0.401,P<0.001).Serum TAM(OR=1.046,95%CI:1.013\|1.080,P=0.007)and serum ALP(OR=1.023,95%CI:1.006\|1.039,P=0.006)were independent risk factors of bone metastasis in non-small-cell lung carcinoma patients.The area under curve were 0.730 for serum TAM and 0.733 for serum ALP in assessing bone metastasis in non-small-cell lung carcinoma patients.The sensitivity were 70%and 54%,the specificity was 78.3%and 86.7%,the optimal cut-off values were 97.145 u/mL and 105 u/L,respectively.There was no significant difference in sensitivity(χ^(2)=1.691,P=0.193)and specificity(χ^(2)=2.652,P=0.103)between TAM and ALP.Conclusion TAM has predictive value for bone metastasis in non-small-cell Lung Carcinoma.

关 键 词：肿瘤相关物质 非小细胞肺癌 骨转移 

分 类 号：R734.2[医药卫生—肿瘤]