宝鸡市金台地区高危型人乳头瘤病毒感染现状分析  

Epidemiological characteristics of high-risk human papillomavirus infection in Jintai District of Baoji

作　　者：王倩 杨鹏[2] 赵秋剑[1] 胡晓红 Wang Qian;Yang Peng;Zhao Qiujian;Hu Xiaohong(Medical Laboratory of Baoji Central Hospital,Baoji 721000,China;Genetic and Eugenic Laboratory of Baoji Maternal and Child Health Hospital,Baoji 721000,China;Baoji Jintai District Maternal and Child Health and Family Planning Service Center,Baoji 721000,China)

机构地区：[1]宝鸡市中心医院检验科,宝鸡721000 [2]宝鸡市妇幼保健院遗传优生实验室,宝鸡721000 [3]宝鸡市金台区妇幼保健计划生育服务中心,宝鸡721000

出　　处：《国际流行病学传染病学杂志》2023年第2期137-140,共4页International Journal of Epidemiology and Infectious Disease

摘　　要：目的了解宝鸡市金台地区高危型HPV流行病学分布特征,以及HPV亚型与宫颈病变的关系。方法选取2021—2022年在宝鸡市金台地区接受宫颈癌筛查的11237名妇女,采用多重荧光PCR技术对其进行HPV基因分型检测,分析不同年龄段的感染率、亚型分布、薄层液基细胞学检测(TCT)及宫颈组织活检病理诊断结果。结果11237名妇女中,共检出HPV阳性1439例,阳性检出率为12.81%。51~55岁组感染率最高(20.79%,501/2410),各年龄段HPV阳性率差异有统计学意义(χ2=310.40,P<0.001)。在HPV初筛阳性患者中,后续TCT筛查完成率仅为62.39%(730/1170)。在高级别宫颈病变中,均以HPV16感染为主(45.71%,16/35),而低级别宫颈病变中,以其他12种HPV亚型为主(86.67%,104/120)。结论宝鸡金台地区高危型HPV感染率较高,以51~55岁感染率最高。高、低级别宫颈病变中HPV亚型有异。初筛阳性患者的后续TCT筛查完成率较低。Objective To investigate the epidemiological distribution of high-risk HPV in Jintai District of Baoji City,and the relationship between HPV subtypes and cervical lesions.Methods A total of 11237 women who received cervical cancer screening in Jintai District of Baoji City from 2021 to 2022 were enrolled for HPV genotyping detection by multiplex PCR.The infection rate,subtype distribution,results of thin-layer liquid-based cytological detection(TCT)and pathological diagnosis of cervical biopsy were analyzed in different age groups.Results There were 1439 HPV-positive cases detected in 11237 women,with a positive detection rate of 12.81%.The positive detection rate in the age group of 51-55 was the highest(20.79%,501/2410),and there were statistical differences in HPV positive rates among different age groups(χ2=310.40,P<0.001).In the patients with positive initial screening for HPV,the completion rate of follow-up TCT screening was only 62.39%(730/1170).In high-grade cervical lesions,HPV16 was the predominant subtype(45.71%,16/35),while other 12 high-risk HPV types were the predominant subtypes in low-grade cervical lesions(86.67%,104/120).Conclusions The infection rate of high-risk HPV is high in Jintai District of Baoji,especially in the age group of 51-55.HPV subtypes are different between high and low-grade cervical lesions.The TCT screening completion rate of HPV-positive patients at the initial screening is low.

关 键 词：乳头状瘤病毒感染 基因分型 年龄分布 宫颈癌 HPV16 

分 类 号：R737.33[医药卫生—肿瘤]