免疫微环境调控转移性肝癌机制研究进展  

Advances in the mechanism of immune microenvironment regulation of metastatic liver cancer

作　　者：郭驹 谢裕安[2] GUO Ju;XIE Yu’an(Graduate School of Guangxi University of Chinese Medicine,Guangxi,Nanning 530021,China;不详)

机构地区：[1]广西中医药大学研究生院,南宁市530200 [2]广西医科大学附属肿瘤医院实验研究部,广西壮族自治区妇幼保健院,南宁市530200

出　　处：《河北医药》2023年第8期1238-1243,共6页Hebei Medical Journal

基　　金：国家重点研发计划项目(编号:2019YFC0121901)。

摘　　要：转移性肝癌仍是癌症相关死亡的主要原因和挑战。肝脏具有促转移、促侵袭等特性,包含了复杂的免疫系统,该系统对肠肝循环产生的新抗原能够一定程度上抑制免疫。本综述以结直肠癌肝转移为背景,重点讨论转移性癌细胞在肝脏中遇到的免疫微环境,分别从先天性免疫和适应性免疫应答方式阐述免疫微环境在转移性肝癌中的调控,既有利于新型治疗策略的制定,又为临床提供参考。Metastatic hepatic carcinoma(MHC)is a main leading cause of cancer-related deaths with a enormous challenge.The liver has the characteristics of pro-metastasis and pro-invasion,involving complex immune system,to some extent,the neoantigens produced by the enterohepatic circulation can suppress the immunity.Based on the background of colorectal cancer liver metastasis,this review focuses on the immune microenvironment of metastatic cancer cells.The regulation of immune microenvironment in MHC was clarified in two ways of innate immunity and adaptive immune response.It is not only helps to the formulation of new treatment strategies,but also provides a reference for clinical practice.

关 键 词：转移性肝癌 免疫微环境 先天性免疫 获得性免疫 结直肠癌肝转移 

分 类 号：R735.7[医药卫生—肿瘤]