从合成生态学角度提高酿酒酵母产2,3-丁二醇的研究进展  

Improving the Production of 2,3-Butanediol by Saccharomyces cerevisiae Using the Theory of Synthetic Ecology:A Review

作　　者：曹鑫博 颜挺威 张文 任焱鑫 裴芳艺 康杰 葛菁萍[1,2] CAO Xinbo;YAN Tingwei;ZHANG Wen;REN Yanxin;PEI Fangyi;KANG Jie;GE Jingping(Engineering Research Center of Agricultural Microbiology Technology,Ministry of Education&Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region&Key Laboratory of Microbiology,College of Heilongjiang Province&School of Life Sciences,Heilongjiang University,Harbin 150080;Hebei University of Environmental Engineering,Hebei Key Laboratory of Agroecological Safety,Qinhuangdao,Hebei 066102)

机构地区：[1]黑龙江大学生命科学学院,农业微生物技术教育部工程研究中心,黑龙江省寒区植物基因与生物发酵重点实验室,黑龙江省普通高校微生物重点实验室,哈尔滨150080 [2]河北环境工程学院,河北省农业生态安全重点实验室,河北秦皇岛066102

出　　处：《中国农学通报》2023年第15期132-138,共7页Chinese Agricultural Science Bulletin

基　　金：黑龙江省自然科学基金重点项目“乙酸代谢与副干酪乳杆菌群体感应互作探究及对细菌素产生的影响”(ZD2020C008);黑龙江大学研究生创新科研项目“蓝靛果多酚与微生物互作预防肥胖及促进废弃物腐殖化的机理研究”(YJSCX2022-031HLJU);黑龙江大学研究生创新科研项目“副干酪乳杆菌HD1.7菌内乙酸溢流对群体感应的影响”(YJSCX2022-239HLJU);黑龙江大学研究生创新科研项目“蓝靛果多酚对致龋菌生物膜的影响及机理初探”(YJSCX2022-093HLJU)。

摘　　要：2,3-丁二醇(2,3-Butanediol,2,3-BD)在化工、医药以及航天等多领域用途广泛,其被称为重要的平台化合物。为了解决2,3-BD需求量巨大且石油紧缺的问题,在分析酿酒酵母生产2,3-BD优势的基础上,探讨了自上而下和自下而上的两种工程微生物群体构建策略,以期利用酿酒酵母和伴生菌株共培养生产2,3-BD。同时本文也从合成生态学角度出发,归纳了合成生态学在恢复生态、医疗以及生产实践方面的应用,并提出利用合成生态学理论促使酿酒酵母生产2,3-BD的可行性。2,3-Butanediol(2,3-BD)is widely used in many fields such as chemical industry,medicine and aerospace,and it is called an important platform compound.In order to solve the problem of huge demand for 2,3-BD and shortage of oil,this paper discusses the top-down and bottom-up construction of engineering microbial populations based on the analysis of the advantages of Saccharomyces cerevisiae in producing 2,3-BD,thus providing strategies to produce 2,3-BD by co-culture of Saccharomyces cerevisiae and companion strains.At the same time,from the perspective of synthetic ecology,this paper also summarizes its application in restoration ecology,medical treatment and production practice,and proposes the feasibility of using synthetic ecology theory to promote the production of 2,3-BD by Saccharomyces cerevisiae.

关 键 词：合成生态学 酿酒酵母 2 3-丁二醇 共培养 工程微生物群体 

分 类 号：S182[农业科学—农业基础科学]