Hedgehog/GLI与胃癌的研究进展与现状  

Hedgehog/GLI and gastric cancer:Research progress and current status

作　　者：池肇春[1] Zhao-Chun Chi(Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao 266011,Shandong Province,China)

机构地区：[1]青岛市市立医院消化内科,山东省青岛市266011

出　　处：《世界华人消化杂志》2023年第10期389-396,共8页World Chinese Journal of Digestology

摘　　要：刺猬/胶质母细胞瘤相关蛋白(相关癌基因同源物)(hedgehog/glioblastoma-interrelated-protein,Hh/GLI)是一个重要的信号通路.现已在多种癌症研究中得到证实,突变或失调的Hh信号可能为干扰肿瘤行为表型,导致多种癌症的发生.异常激活的Hh通路赋予肿瘤细胞发生、增殖和迁移的倾向.近几年又研究发现Hh信号通路诱导胃癌(gastric cancer,GC)侵袭和上皮间质转化.本文就Hh/GLI与GC相关的研究进展与现状作一评述.揭开GC发生的新面纱,将为Hh/GIL靶向治疗GC开辟了新途径.Hedgehog/GLI(Hh/GLI)is an important signaling pathway.It has been confirmed in various cancer studies that mutated or dysregulated Hh signals may be the behavioral phenotype of tumors,leading to the occurrence of various cancers.The abnormally activated Hh pathway endows tumor cells with a tendency to occur,proliferate,and migrate.In recent years,studies have found that the Hh signaling pathway induces gastric cancer(GC)invasion and epithelial mesenchymal transition.This article reviews the research progress and current status of Hh/GLI related to GC.Unveiling the new veil of GC occurrence will open a new approach for targeted therapy of this malignancy.

关 键 词：Hh/GLI 信号通路 胃癌 干细胞 半乳糖凝集素 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]