SR、miR-126、TGF-β1与未破裂颅内动脉瘤栓塞术后复发的关系及联合预测复发的ROC分析  

The relationship between SR,miR-126,TGF-β1 and recurrence after embolization of unruptured intracranial aneurysm and ROC analysis for combined prediction of recurrence

作　　者：李凤鹏 靳玫[1] 赵敏 LI Fengpeng;JIN Mei;ZHAO Min(Department of Neurology,Third Affiliated Hospital of Xinxiang Medical College,Henan Xinxiang 453000)

机构地区：[1]新乡医学院第三附属医院神经内科,河南新乡453000 [2]郑州大学附属郑州中心医院神经内科,河南郑州450000

出　　处：《医学检验与临床》2023年第4期25-29,5,共6页Medical Laboratory Science and Clinics

摘　　要：目的:探讨瘤体最大径与载瘤动脉管径之比(SR)、微小RNA-126(miR-126)、转化生长因子β1(TGF-β1)与未破裂颅内动脉瘤(IA)栓塞术后复发的关系,并分析各指标联合预测复发的价值。方法:选取2016年7月-2021年6月新乡医学院第三附属医院103例未破裂IA患者,均行单纯弹簧圈栓塞或支架辅助弹簧圈栓塞术治疗,统计手术结果及术后6个月复发情况,根据是否复发分为复发组、未复发组,比较两组治疗前基线资料、SR、血清miR-126、TGF-β1水平,分析血清miR-126、TGF-β1与SR的相关性,并分析SR、miR-126、TGF-β1预测未破裂IA术后复发的价值。结果:本组103例未破裂IA患者,手术治疗成功率为100%,术后6个月内复发率为15.53%;复发组动脉瘤10~25mm患者占比、存在子瘤患者占比、SR及血清miR-126、TGF-β1水平均高于未复发组(P<0.05);未破裂IA患者治疗前血清miR-126、TGF-β1水平与SR呈正相关(P<0.05);治疗前SR、miR-126、TGF-β1均为未破裂IA患者术后复发的影响因素(P<0.05);治疗前SR、miR-126、TGF-β1预测未破裂IA患者术后复发的曲线下面积(AUC)均>0.7,各指标联合预测复发的AUC最大,为0.956,最佳预测敏感度、特异度分别为93.75%、91.95%。结论:SR、血清miR-126、TGF-β1均为未破裂IA患者术后复发的影响因素,各指标联合可为临床预测术后复发提供辅助参考。Objective:To investigate the ratio of the maximum diameter of the tumor to the diameter of the parent artery(SR),microRNA-126(miR-126),transforming growth factorβ1(TGF-β1)and unruptured intracranial aneurysm(IA)embolization The relationship between postoperative recurrence,and the value of each index combined to predict recurrence was analyzed.Methods:103 patients with unruptured IA in XXX Hospital from July 2016 to June 2021 were selected,and all underwent simple coil embolization or stent-assisted coil embolization,and the operation results and postoperative 6-month recurrence,according to the recurrence or not,they were divided into recurrence group and non-recurrence group.Baseline data,SR,serum miR-126 and TGF-β1 levels before treatment were compared between the two groups,and serum miR-126,TGF-β1 and SR levels were analyzed.The correlations were analyzed,and the value of SR,miR-126 and TGF-β1 in predicting postoperative recurrence of unruptured IA was analyzed.Results:In this group of 103 patients with unruptured IA,the success rate of surgical treatment was 100%,and the recurrence rate within 6 months after surgery was 15.53%.The levels of SR,serum miR-126 and TGF-β1 were higher than those of the non-relapse group(P<0.05);The levels of serum miR-126 and TGF-β1 in patients with unruptured IA before treatment were positively correlated with SR(P<0.05);SR,miR-126 and TGF-β1 before treatment were all influencing factors of postoperative recurrence in patients with unruptured IA(P<0.05);Before treatment,the area under the curve(AUC)of SR,miR-126 and TGF-β1 for predicting postoperative recurrence of unruptured IA patients were all>0.7.They were 93.75%and 91.95%respectively.Conclusion:SR,serum miR-126 and TGF-β1 are all influencing factors of postoperative recurrence in patients with unruptured IA,and the combination of each index can provide an auxiliary reference for clinical prediction of postoperative recurrence.

关 键 词：未破裂颅内动脉瘤 瘤体最大径与载瘤动脉管径之比 微小RNA-126 转化生长因子β1 复发 

分 类 号：R739.41[医药卫生—肿瘤]