铁死亡:腹主动脉瘤防治新靶点?  

Ferroptosis:a new target for the prevention and treatment of abdominal aortic aneurysm?

作　　者：周雅婷 向琼[1] 廖韦 夏梦蝶 刘录山[1] 唐志晗[1] 彭娟[1] ZHOU Yating;XIANG Qiong;LIAO Wei;XIA Mengdie;LIU Lushan;TANG Zhihan;PENG Juan(Institute of Cardiovascular Disease,University of South China&Key Laboratory for Arteriosclerology of Hunan Province&Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室湖南省动脉硬化性疾病国际科技创新合作基地,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2023年第6期527-532,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81770454);湖南省自然科学基金项目(2022JJ30510);湖南省研究生科研创新项目资助(CX20221002)。

摘　　要：铁死亡是一种铁依赖性的、非凋亡型的程序性细胞死亡方式,其主要特征是铁代谢紊乱导致细胞内铁超载,通过芬顿反应诱导脂质过氧化,激活铁死亡。铁死亡与诸多疾病相关,其中与腹主动脉瘤的关系近来受到关注。腹主动脉瘤是一种以腹主动脉壁结构破坏、不可逆性扩张为主要特征的退行性病变,其发病机制与氧化应激、炎症反应、血管平滑肌细胞丢失及血管钙化有关。铁死亡可能通过上述途径参与腹主动脉瘤的发生。因此,本文对铁死亡和腹主动脉瘤的致病机制进行综述,为腹主动脉瘤的治疗提供新思路和新靶点。Ferroptosis is an iron-dependent,non-apoptotic programmed cell death characterized by iron metabolism disorder that leads to intracellular iron overload,which induces lipid peroxidation through fenton reaction and activates ferroptosis.Ferroptosis is associated with many diseases,among which the relationship with abdominal aortic aneurysm has come into attention in the last few years.Abdominal aortic aneurysm is a degenerative disease characterized by structural destruction and irreversible dilation of the abdominal aortic wall.Its pathogenesis is related to oxidative stress,inflammation,loss of vascular smooth muscle cells and vascular calcification.Ferroptosis may play a role in the development of abdominal aortic aneurysm through the above pathways.Therefore,this paper reviews the pathogenesis of ferroptosis and abdominal aortic aneurysm,providing a new idea and target for the abdominal aortic aneurysm treatment.

关 键 词：铁死亡 腹主动脉瘤 铁代谢 血管平滑肌细胞 氧化应激 炎症 血管钙化 

分 类 号：R363[医药卫生—病理学] R5[医药卫生—基础医学]