Prognostic value of the long noncoding RNA AFAP1-AS1 in cancers  

作　　者：Lixiu Zhu Jiawen Yan Guoqiang Xu Qiaoli Wang Tianrui Xu Ruixue Cao Chuanzheng Sun Yan Xi Wei Xiong 

机构地区：[1]Department of Radiotherapy,Yunnan Cancer Hospital,The Third Affiliated Hospital of Kunming Medical University,Kunming 650000,China [2]Department of Radiotherapy,People's Hospital of Yuxi City,The Sixth Affiliated Hospital of Kunming Medical University,Yuxi 653100,China [3]Department of Head and Neck Surgery,Yunnan Cancer Hospital,The Third Affiliated Hospital of Kunming Medical University,Kunming 650000,China

出　　处：《Oncology and Translational Medicine》2023年第3期133-146,共14页肿瘤学与转化医学（英文版）

基　　金：Supported by a grant from the“Ten Thousand Plan”Youth Talent Project in Yunnan Province(no grant number is applicable).

摘　　要：Objective This meta-analysis explored whether the expression of actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)is related to the prognosis and clinicopathological features of patients with cancer.Methods PubMed,EMBASE,and Cochrane Library were systematically searched.Hazard ratios(HRs)with 95%confidence intervals(CIs)were used to assess the prognostic value based on overall survival(OS),disease-free survival(DFS),and progression-free survival(PFS).Odds ratios(ORs)with 95%CIs were used to determine the relationships between AFAP1-AS1 and clinicopathological features,such as large tumor size(LTS),high tumor stage(HTS),poor histological grade(PHG),lymph node metastasis(LNM),and distant metastasis(DM).Results Thirty-five eligible articles and 3433 cases were analyzed.High AFAP1-AS1 expression,compared to low AFAP1-AS1 expression,correlated with significantly shorter OS(HR=2.15,95%CI=1.97-2.34,P<0.001),DFS(HR=1.37,95%CI=1.19-1.57,P<0.001),and PFS(HR=1.97,95%CI=1.56-2.50,P<0.001)in patients with cancer.In various cancers,elevated AFAP1-AS1 expression was significantly associated with LTS(OR=2.76,95%CI=2.16-3.53,P<0.001),HTS(OR=2.23,95%CI=1.83-2.71,P<0.001),and PHG(OR=1.39,95%CI=1.08-1.79,P=0.01)but not LNM(OR=1.59,95%CI=0.88-2.85,P=0.12)or DM(OR=1.81,95%CI=0.90-3.66,P=0.10).Conclusion High AFAP1-AS1 expression was associated with prognostic and clinicopathological features,suggesting that AFAP1-AS1 is a prognostic biomarker for human cancers.

关 键 词：long noncoding RNA(lncRNA) actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1) PROGNOSTIC META-ANALYSIS 

分 类 号：R730.4[医药卫生—肿瘤]