腹膜假黏液瘤的预后影响因素分析  

Analysis of prognostic factors of pseudomyxoma peritonei

作　　者：翟梦洁 王军陶 姜中歌 赵星浩 杨秋云 刘广芝 ZHAI Meng-jie;WANG Jun-tao;JIANG Zhong-ge;ZHAO Xing-hao;YANG Qiu-yun;LIU Guang-zhi(Department of Obstetrics and Gynecology,People's Hospital of Zhengzhou University,Henan Provincal People's Hospital,Zhengzhou 450003,China;Heyou Meihe Hospital,Foshan,Guangdong 528306,China;Internation Medical Center of Henan Provincial People's Hospital,Zhengzhou 450003,China;Henan key Laboratory of Stem Cell Differentiation and Modification,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院妇产科,河南省人民医院,郑州450003 [2]和祐美和医院,广东佛山528306 [3]河南省人民医院国际医疗中心,郑州450003 [4]河南省干细胞调控与分化中心,郑州450003

出　　处：《医药论坛杂志》2023年第6期11-13,17,共4页Journal of Medical Forum

基　　金：河南省软科学研究计划项目(152400410224)。

摘　　要：目的 探讨腹膜假黏液瘤(pseudomyxoma peritonei,PMP)的临床特点并分析预后的影响因素。方法 回顾性分析2015年3月至2021年3月郑州大学人民医院诊治的33例PMP患者的临床资料,根据PMP患者的预后情况,分为死亡组(13例)和生存组(20例),并分析PMP患者预后的影响因素。结果 33例患者均有效随访,两组患者单因素分析显示术前血清肿瘤标志物水平、肿瘤细胞减灭程度评分及病理类型方面差异具有统计学意义(P<0.05)。多因素logistic回归分析结果显示病理类型是影响PMP患者生存期的独立因素(HR>1,P<0.05)。病理亚组单因素分析显示低级别弥漫性腹膜黏液腺瘤病术中行满意减瘤术的患者预后更好,差异具有统计学意义(P<0.05)。结论 病理类型是影响PMP患者预后的独立危险因素,术中满意减瘤术可改善低级别弥漫性腹膜黏液腺瘤病患者预后。Objective To investigate the clinical characteristics and prognosis of pseudomyxoma peritonei(PMP).Methods The clinical data of 33 PMP patients treated in Zhengzhou University People's Hospital from March 2015 to March 2021 were retrospectively analyzed.According to the prognosis of PMP patients,they were divided into death group(n=13) and survival group(n=20),and the influencing factors of prognosis of PMP patients were analyzed.Results All 33 patients were followed up effectively.Univariate analysis showed that there were statistically significant differences in preoperative serum tumor marker level,tumor cell extinction degree score and pathological type between the two groups(P<0.05).Multivariate logistic regression analysis showed that pathological type was an independent factor affecting the survival of PMP patients(HR>1,P<0.05).Pathological subgroup univariate analysis showed that patients with low-grade diffuse peritoneal mucinous adenomatosis who underwent satisfactory reduction surgery had better prognosis,and the difference was statistically significant(P<0.05).Conclusion Pathological type is an independent risk factor affecting the prognosis of PMP patients.Satisfactory intraoperative reduction of tumor can improve the prognosis of patients with low-grade diffuse peritoneal mucinous adenoma.

关 键 词：腹膜假黏液瘤 腹腔热灌注化疗 预后 影响因素 

分 类 号：R735.5[医药卫生—肿瘤]