经尿道前列腺电切术联合内分泌去势疗法治疗晚期前列腺癌的临床疗效  

Clinical effects of transurethral resection of prostate combined with endocrine castration in the treatment of advanced prostate cancer

作　　者：郭秀彦 刘素花[1] 程沛[1] 录玲玲[1] GUO Xiu-yan;LIU Su-hua;CHENG Pei;LU Ling-ling(Department of Urology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院泌尿外科,郑州450014

出　　处：《医药论坛杂志》2023年第7期15-18,22,共5页Journal of Medical Forum

基　　金：2021年度河南省医学科技攻关计划联合共建项目和软科学项目(LHGJ20210430)。

摘　　要：目的 研究经尿道前列腺电切术联合内分泌去势疗法治疗晚期前列腺癌的临床效果。方法 从2017年1月11日至2019年1月11日,收集郑州大学第二附属医院收入治疗的晚期前列腺癌患者中,选取114例作为此次研究对象,根据治疗方式不同分为对照组和观察组,将内分泌去势疗法患者设为对照组(57例),将经尿道前列腺电切术联合内分泌去势疗法设为观察组(57例),观察对比两组患者生活质量、实验室各项指标、治疗总有效率和三年的生存率。结果 治疗前,两组生活质量相比差异无统计学意义(P>0.05),治疗后,两组生活质量均有改善,且对比提示观察组优于对照组,P<0.05。治疗前,两组实验室各项指标相比差异无统计学意义(P>0.05),治疗后,观察组前列腺特异性抗原(PSA)和血管内皮生长因子(VEGF)的水平较对照组低,最大的尿流率较对照组高,残余尿量较对照组少,P<0.05。观察组治疗总有效率为96.49%,与对照组的84.21%相比明显增高,对比差异有统计学意义(P<0.05)。观察组1年生存率100.00%,两年生存率91.23%,三年生存率77.19%,均较对照组的87.72%、71.93%、49.12%明显增高,P<0.05。结论 在晚期前列腺癌患者治疗中,应用经尿道前列腺电切术联合内分泌去势疗法,能对患者前列腺的症状、排尿的情况及生活质量起到有效改善作用,并提升其治疗效果和三年的生存率。Objective To study the clinical effect of transurethral resection of prostate combined with endocrine castration in the treatment of advanced prostate cancer.Methods From January 11,2017 to January 11,2019,114 cases of advanced prostate cancer patients in the Second Affiliated Hospital of Zhengzhou University were collected as the study object,and were divided into control group and observation group by digital random table method.The patients with endocrine castration were divided into control group(57 cases),and with transurethral resection of prostate combined with endocrine castration were divided into observation group(57 cases).Quality of life,laboratory indexes,total effective rate and three-year survival rate of the two groups were observed and compared.Results Before treatment,there was no significant difference in the quality of life between the two groups(P>0.05).After treatment,the quality of life of the two groups was improved,and the comparison indicated that the observation group was better than the control group,P<0.05.Before treatment,there was no statistically significant difference in laboratory indicators between the two groups(P>0.05).After treatment,the levels of PSA and VEGF in the observation group were lower than those in the control group,the maximum urine flow rate was higher,and the residual urine volume was lower than that in the control group,P<0.05.The total effective rate of the observation group was 96.49%,which was significantly higher than that of the control group(84.21%),and the difference was statistically significant(P<0.05).The 1-year survival rate was 100.00%,the 2-year survival rate was 91.23% and the 3-year survival rate was 77.19% in the observation group,which were significantly higher than 87.72%,71.93% and 49.12% in the control group(P<0.05).Conclusion In the treatment of advanced prostate cancer patients,the application of transurethral resection of prostate combined with endocrine castration can effectively improve the prostate symptoms,urinary status and quality o

关 键 词：晚期前列腺癌 经尿道前列腺电切术 内分泌去势疗法 临床效果 

分 类 号：R737.25[医药卫生—肿瘤]