中心性浆液性脉络膜视网膜病变患者视网膜下积液和干眼严重程度的相关性  

Correlation between subretinal fluid and dry eye severity in central serous chorioretinopathy patients

作　　者：吕英楠 秦廷玉[1] 王文战[1] LÜ Yingnan;QIN Tingyu;WANG Wenzhan(Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第一附属医院眼科,河南省郑州市450052

出　　处：《眼科新进展》2023年第6期463-466,共4页Recent Advances in Ophthalmology

基　　金：河南省高等学校重点科研项目(编号:19A320059)。

摘　　要：目的探讨中心性浆液性脉络膜视网膜病变(CSC)患者视网膜下积液(SRF)和干眼严重程度的相关性。方法选取2018年9月至2022年9月于郑州大学第一附属医院眼科就诊的CSC患者115例(115眼)。依据干眼的严重程度分为三组,干眼组(51例):泪液分泌试验(SⅠt)(无表面麻醉)为0~5 mm/5 min或泪膜破裂时间(BUT)为0~5 s,轻度干眼组(47例):SⅠt(无表面麻醉)>5 mm/5 min~10 mm/5 min或BUT>5~10 s,非干眼组(17例):SⅠt(无表面麻醉)>10 mm/5 min及BUT>10 s。利用OCT测量所有患者SRF高度及神经上皮层脱离宽度。分析各组患者性别比例、吸烟人数比例、睡眠不足比例、患者SRF高度及神经上皮层脱离宽度的差异。结果三组患者年龄分布差异无统计学意义(P=0.565)。三组患者性别比较差异有统计学意义(P=0.000),两两比较结果显示,干眼组与轻度干眼组患者性别比例差异无统计学意义(P=0.825),干眼组与非干眼组、轻度干眼组与非干眼组患者性别比例差异均有统计学意义(均为P<0.05)。干眼组、轻度干眼组、非干眼组患者的吸烟人数比例,睡眠不足比例依次降低,差异均有统计学意义(均为P=0.000),两两比较结果显示,三组患者的吸烟人数比例、睡眠不足比例差异均有统计学意义(均为P<0.05)。干眼组、轻度干眼组、非干眼组患者的SRF高度依次降低,分别为(387.16±48.28)μm、(236.94±49.32)μm、(142.24±52.78)μm,差异有统计学意义(P=0.000)。干眼组、轻度干眼组、非干眼组患者的神经上皮层脱离宽度依次减小,分别为(3402.12±511.76)μm、(1601.28±394.11)μm、(574.06±209.49)μm,差异有统计学意义(P=0.000)。两两比较结果显示,干眼组与轻度干眼组、干眼组与非干眼组、轻度干眼组与非干眼组患者SRF高度及神经上皮层脱离宽度差异均有统计学意义(均为P<0.05)。结论CSC好发于中青年男性,患者往往伴有干眼;CSC患者的SRF与干眼的严重程度具有一定的相�Objective To explore the correlation between the severity of dry eye and subretinal fluid(SRF)in patients with central serous chorioretinopathy(CSC).Methods A total of 115 CSC patients(115 eyes)who visited the Department of Ophthalmology of the First Affiliated Hospital of Zhengzhou University from September 2018 to September 2022 were included.Based on the severity of dry eye,the patients were divided into 3 groups:dry eye group[51 patients,Schirmer I test(SⅠt,without anesthesia)result:0(exclusive)-5 mm/5 min,or tear film break-up time(BUT):0-5 s],mild dry eye group[47 patients,SⅠt(without anesthesia)result:>5(exclusive)-10 mm/5 min,or BUT:>5-10 s]and non-dry eye group[17 patients,SⅠt(without anesthesia)result>10 mm/5 min,and BUT>10 s].The height of SRF and the width of neuroepithelial detachment in all CSC patients were measured by optical coherence tomography.Differences in gender distribution,ratios of smokers and sleep deprivation patients,height of SRF and width of neuroepithelial detachment were analyzed.Results There was no significant difference in the age distribution among the three groups(P=0.565).There was a significant difference in the gender distribution among the three groups(P=0.000);the pairwise comparisons showed no significant difference between the dry eye group and the mild dry eye group(P=0.825)but significant differences between the dry eye group and non-dry eye group,mild dry eye group and non-dry eye group(both P<0.05).The ratios of smokers and sleep deprivation patients decreased successively in the dry eye group,mild dry eye group and non-dry eye group,with significant differences(both P=0.000);the pairwise comparisons showed significant differences in the ratios of smokers and sleep deprivation patients(all P<0.05).The height of SRF decreased sequentially in the dry eye group,mild dry eye group and non-dry eye group,which were(387.16±48.28)μm,(236.94±49.32)μm and(142.24±52.78)μm,respectively(P=0.000).The width of neuroepithelial detachment decreased sequentially in the dr

关 键 词：中心性浆液性脉络膜视网膜病变 干眼 视网膜下积液 神经上皮层脱离宽度 

分 类 号：R774[医药卫生—眼科]