纳洛酮对抗精神病药物中毒患者的认知功能及负面情绪的影响  

Effects of naloxone on cognitive function and negative emotions in patients with antispermatogenic drug poisoning

作　　者：韩永旭 马西凡 孙枫林 HAN Yong;MA Xifan;SUN Fenglin(Emergency Department,Xuchang Central Hopital,Xuchang 461000,China)

机构地区：[1]许昌市中心医院急诊科,许昌461000

出　　处：《国际精神病学杂志》2023年第2期268-271,共4页Journal Of International Psychiatry

摘　　要：目的 探究纳洛酮对抗精神病药物中毒患者的临床治疗效果及对患者预后认知功能、负面情绪的影响价值。方法 选取我科2020年4月~2021年10月期间109例抗精神病药物中毒患者为研究对象,根据随机数字表法分为两组,对照组54例给予对症治疗,观察组55例在常规治疗的基础上增加纳洛酮治疗,对比两组患者各项指标。结果 治疗后,观察组患者格拉斯哥昏迷评分法高于对照组,观察组患者催醒时间、醒后症状维持时间均低于对照组(P<0.05);治疗成功1周后、2周后,观察组患者焦虑自评量表(Self-rating anxiety scale,SAS)、抑郁自评量表(Self-rating depression scale,SDS)评分低于对照组,简易精神状态检查量表(Mini-mental state examination,MMSE)评分高于对照组(P<0.05);治疗成功2周后,两组患者锥体外系副反应量表(A rating scale for extrapyramidal side effects,RSESE)评分对比无明显差异(P>0.05),但观察组患者社会功能缺陷筛查量表(Social disability screening schedule,SDSS)评分低于对照组(P<0.05);两组患者并发症发生率对比无明显差异(P>0.05)。结论 纳洛酮可以提高对患者的临床诊疗效果,降低患者负面情绪水平,提高其认知功能水平、社会功能水平,安全性高。Objective e To explore the clinical treatment effect of naloxone in patients with antispermatogenic drug poisoning and its influence value on patients'prognostic cognitive function and negative emotions.Methods From 2020 April to October 2021,109 antipsychotic poisoning patients were chose as the research object,according to random number table method,they were divided into two groups,54 patients in the control group with symptomatic treatment,55 cases in the observation group increase naloxone treatment on the basis of conventional treatment.The indicators were compared between two group.Results After treatment,the Glasgow Coma Score of the patients in the observation group was higher than that of the control group,and the wake-up time and symptom maintenance time of the patients in the observation group were lower than that of the control group(P<0.05).After 1 week and 2 weeks of successful treatment,the scores of self-rating Anxiety Scale(SAS)and self-rating Depression Scale(SDS)in the observation group were lower than those in the control group,and the scores of Mini Mental State Examination(MMSE)were higher than those in the control group(P<0.05).After 2 weeks of successful treatment,there was no significant difference in the scores of extravertebral side effects(RSESE)between the two groups(P>0.05),but the scores of social disability screening schedule(SDSS)in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Naloxone can improve the clinical effect of patients,reduce the level of negative emotions,improve the level of cognitive and social function with high safety.

关 键 词：纳洛酮 抗精神药物中毒 负面情绪 锥体外系不良反应 认知功能 

分 类 号：R749.05[医药卫生—神经病学与精神病学]