淋巴结转移对G2期胰腺神经内分泌肿瘤患者预后的影响  

Effect of lymph node metastasis on the prognosis of patients with G2 phase stage pancreatic neuroendocrine tumors

作　　者：张欣雪[1] 马军[1] 吕少诚[1] 许文犁 寇建涛[1] 贺强[1] Zhang Xinxue;Ma Jun;Lyu Shaocheng;Xu Wenli;Kou Jiantao;He Qiang(Department of Hepatobiliary Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院肝胆外科,北京100020

出　　处：《国际外科学杂志》2023年第4期236-240,共5页International Journal of Surgery

摘　　要：目的探讨淋巴结转移对G2期胰腺神经内分泌肿瘤(pNEN)患者预后的影响。方法采用回顾性病例对照研究方法分析SEER数据库2010年1月1日—2016年12月31日368例G2期pNEN患者的病例资料,其中男性174例,女性194例。根据淋巴结是否转移分为淋巴结无转移(N0)组(n=272)和淋巴结有转移(N1)组(n=96),采用Kaplan-Meier法及Log-rank检验比较N0组、N1组患者总体生存率(OS),COX比例风险模型评估N分期是否为影响预后的独立危险因素。计数资料以例数和百分率(%)表示,组间比较采用χ^(2)检验。结果在所有患者中,N0组患者的OS优于N1组患者。N0组患者的1、3、5年的OS分别为96.3%、92.7%和85.6%,N1组患者的1、3、5年的OS分别为92.6%、82.1%和82.1%(P=0.014)。多因素分析显示,年龄(HR=2.245,95%CI:1.126~4.475,P=0.022)、N分期(HR=0.457,95%CI:0.237~0.883,P=0.020)是G2期pNEN患者的独立预后因素。结论淋巴结转移是G2期pNEN患者的独立预后因素之一。Objective To investigate the effect of lymph node metastasis on the prognosis of patients with G2 phase stage pancreatic neuroendocrine neoplasm(pNEN).Methods A retrospective case control study was conducted to analyze the case data of 368 patients with pancreatic neuroendocrine tumors in G2 phase stage from January 1,2010 to December 31,2016 in SEER database,including 174 males and 194 females.According to whether lymph nodes were metastatic,they are divided into lymph node non metastatic(N0)group(n=272)and lymph node metastatic(N1)group(n=96).The Kaplan-Meier method and Log-rank test were used to compare the overall survival rate(OS)of patients in the N0 and N1 groups.The COX proportional risk model was used to evaluate whether N stage was an independent risk factor affecting prognosis.Count data were expressed as cases and percentage(%),and Chi-square test was used for comparison between the groups.Results Among all patients,the OS of patients in the N0 group was better than that of patients in the N1 group.The OS of N0 patients at 1,3,and 5 years was 96.3%,92.7%,and 85.6%,respectively,while the OS of N1 patients at 1,3,and 5 years was 92.6%,82.1%,and 82.1%,respectively(P=0.014).Multivariate analysis showed that age(HR=2.245,95%CI:1.126-4.475,P=0.022)and N stage(HR=0.457,95%CI:0.237-0.883,P=0.020)were independent prognostic factors for G2 phase pNEN patients.Conclusion Lymph node metastasis is one of the independent prognostic factors in patients with G2 phase stage pNEN.

关 键 词：内分泌腺肿瘤 神经内分泌瘤 淋巴转移 胰腺神经内分泌肿瘤 

分 类 号：R735.9[医药卫生—肿瘤]