Epidemiology of small intestinal bacterial overgrowth  

作　　者：Irina Efremova Roman Maslennikov Elena Poluektova Ekaterina Vasilieva Yury Zharikov Andrey Suslov Yana Letyagina Evgenii Kozlov Anna Levshina Vladimir Ivashkin 

机构地区：[1]Department of Internal Medicine,Gastroenterology and Hepatology,Sechenov University,Moscow 119435,Russia [2]The Scientific Community for Human Microbiome Research,Moscow 119435,Russia [3]Department of Human Anatomy and Histology,Sechenov University,Moscow 125009,Russia [4]N.V.Sklifosovsky Institute of Clinical Medicine,Sechenov University,Moscow 119991,Russia [5]Department of Clinical Immunology and Allergy,Sechenov University,Moscow 119991,Russia

出　　处：《World Journal of Gastroenterology》2023年第22期3400-3421,共22页世界胃肠病学杂志（英文版）

摘　　要：Small intestinal bacterial overgrowth(SIBO)is defined as an increase in the bacterial content of the small intestine above normal values.The presence of SIBO is detected in 33.8%of patients with gastroenterological complaints who underwent a breath test,and is significantly associated with smoking,bloating,abdominal pain,and anemia.Proton pump inhibitor therapy is a significant risk factor for SIBO.The risk of SIBO increases with age and does not depend on gender or race.SIBO complicates the course of a number of diseases and may be of pathogenetic significance in the development of their symptoms.SIBO is significantly associated with functional dyspepsia,irritable bowel syndrome,functional abdominal bloating,functional constipation,functional diarrhea,short bowel syndrome,chronic intestinal pseudo-obstruction,lactase deficiency,diverticular and celiac diseases,ulcerative colitis,Crohn’s disease,cirrhosis,metabolic-associated fatty liver disease(MAFLD),primary biliary cholangitis,gastroparesis,pancreatitis,cystic fibrosis,gallstone disease,diabetes,hypothyroidism,hyperlipidemia,acromegaly,multiple sclerosis,autism,Parkinson’s disease,systemic sclerosis,spondylarthropathy,fibromyalgia,asthma,heart failure,and other diseases.The development of SIBO is often associated with a slowdown in orocecal transit time that decreases the normal clearance of bacteria from the small intestine.The slowdown of this transit may be due to motor dysfunction of the intestine in diseases of the gut,autonomic diabetic polyneuropathy,and portal hypertension,or a decrease in the motor-stimulating influence of thyroid hormones.In a number of diseases,including cirrhosis,MAFLD,diabetes,and pancreatitis,an association was found between disease severity and the presence of SIBO.Further work on the effect of SIBO eradication on the condition and prognosis of patients with various diseases is required.

关 键 词：Gut microbiota Gut-liver axis Breath test LACTULOSE METHANE Hydrogen 

分 类 号：R574.5[医药卫生—消化系统]