Efficacy and safety of modified tetracycline dosing in a quadruple therapy for Helicobacter pylori:A retrospective single center study  

作　　者：Ying-Chao Sun Meng-Jia Zhu Xue-Qin Chen Lei Yue Yi-Ru Zhao Xin-Jie Wang John J Kim Qin Du Wei-Ling Hu 

机构地区：[1]Department of Gastroenterology,Sir Run Run Shaw Hospital,Medical School,Zhejiang University,Hangzhou 310016,Zhejiang Province,China [2]Division of Gastroenterology,Loma Linda University Health,Loma Linda,CA 92354,United States [3]Department of Gastroenterology,Zhejiang University School of Medicine Second Affiliated Hospital,Hangzhou 310009,Zhejiang Province,China [4]Institute of Gastroenterology,Zhejiang University,Hangzhou 310016,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2023年第22期3508-3518,共11页世界胃肠病学杂志（英文版）

基　　金：Supported by the Zhejiang Provincial Natural Science Foundation,No.LY23H160016;Zhejiang Medical Association,No.2019ZYC-A88.

摘　　要：BACKGROUND Although highly effective as a component of Helicobacter pylori(H.pylori)treatment regimen,tetracycline is associated with a high incidence of medicationrelated adverse events.Modified dosing of tetracycline as part of quadruple therapy may improve safety while providing comparable eradication rates.AIM To evaluate the efficacy and safety of modified dosing of tetracycline in patients receiving tetracycline and furazolidone-containing quadruple therapy in patients with H.pylori infection.METHODS Consecutive patients(10/2020-12/2021)who received tetracycline and furazolidone quadruple therapy for H.pylori infection at Sir Run Run Shaw Hospital were identified.All patients received tetracycline,furazolidone,proton pump inhibitor,and bismuth for 14 d as primary or rescue therapy.Modified tetracycline dose group received tetracycline 500 mg twice daily while standard group received 750 mg twice daily or 500 mg three times daily.RESULTS Three hundred and ninety-four patients[mean age=46.3±13.9,male=137(34.8%),and 309(78.4%)primary therapy]completed tetracycline and furazolidone quadruple therapy for H.pylori infection including those who received modified tetracycline dose in 157 and standard doses in 118(750 mg twice daily)and 119(500 mg three times daily).Eradication rates in the modified tetracycline dose group were 92.40%and in the standard groups,eradication rates were 93.20%for 750 mg twice daily group and 92.43%for 500 mg three times daily group,respectively,without statistical difference(P=0.959).The incidence of adverse events was lower in the modified tetracycline dose(15.3%vs 32.3%and 29.4%;P=0.002)compared to the standard dose group.CONCLUSION In a real-world experience,modified tetracycline dosing as part of tetracycline and furazolidone quadruple therapy for 14 d demonstrated high efficacy,comparable to standard tetracycline dose regimens,with a favorable safety profile.

关 键 词：Helicobacter pylori TETRACYCLINE FURAZOLIDONE ERADICATION Penicillin allergy Bismuth quadruple therapy 

分 类 号：R573[医药卫生—消化系统]