STEAP2在多形性胶质母细胞瘤中的表达及预后分析  

Expression and Prognostic Analyses of the Significance of STEAP2 in Glioblastoma Multiforme

作　　者：庞春晓 张文学 李伟[1,2] 杨慧[1,2] 李双双 胡良昌 王金鹏 Pang Chunxiao;Zhang Wenxue;Li Wei;Yang Hui;Li Shuangshuang;Hu Liangchang;Wang Jinpeng(Department of Neurosurgey,Weifang People's Hospital,Weifang 261000,China;The First Afiliated Clinical Medical College of Weifang Medical College,Weifang 261000,China;The Affiliated Clinical Medical College of Weifang Medical College,Weifang 261053,China)

机构地区：[1]潍坊市人民医院神经外科,山东潍坊261000 [2]潍坊医学院第一临床医学院,山东潍坊261000 [3]潍坊医学院临床医学院,山东潍坊261053

出　　处：《南开大学学报（自然科学版）》2023年第2期85-89,共5页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：潍坊医学院博士启动基金(041005)。

摘　　要：多形性胶质母细胞瘤(GBM)是癌症相关死亡率的主要致死因素.STEAP2在多种肿瘤中过表达.本研究的目的是评估STEAP2在GBM患者中的表达和预后价值.使用GEPIA和Kaplan-Meier(KM)分析STEAP2的mRNA表达和蛋白表达及其预后特征.KEGG通路分析用于探索STEAP2的相关信号通路.GEPIA的分析表明,GBM组织中STEAP2的表达上调,STEAP2表达与癌症的临床分期有关.免疫组织化学分析显示,与邻近组织相比,胶质瘤组织中STEAP2蛋白表达显著上调.STEAP2的表达与胶质瘤细胞的增殖能力呈正相关.KM曲线显示,STEAP2表达上调与GBM不良预后有关.STEAP2有望成为胶质瘤的潜在诊断和预后标志物为胶质瘤提供更准确的预后指标.Glioblastoma multiforme(GBM) is the leading cause of cancer-related mortality. STEAP2 is overexpressed in various cancers. This study aimed to evaluate the expression and prognostic value of STEAP2 in patients with GBM. The m RNA expression and protein expression of STEAP2 and its prognostic characteristics were examined using Oncomine, GEPIA, and Kaplan-Meier(KM) plotters. KEGG pathway analysis was used to explore the related signal pathways of STEAP2. Immunohistochemical methods were used to compare the expression of STEAP2 in normal brain and GBM tissues. Analysis of GEPIA showed that STEAP2 expression was related to the clinical stage of GBM. Immunohistochemical analysis showed that STEAP2 protein expression was significantly upregulated in GBM compared to that in normal brain tissues. The expression of STEAP2 was positively correlated with the proliferation abilities of GBM cells. The KM curve showed that the upregulation of STEAP2 expression was related to a bad GBM prognosis. STEAP2 are expected to be potential diagnostic and prognostic markers for GBM, which may provide more accurate prognostic indicators for GBM.

关 键 词：GBM 患者预后 前列腺6跨膜上皮抗原2 生物标志物 

分 类 号：Q812[生物学—生物工程]