超声对甲状腺乳头状癌的诊断价值及与微血管密度、肿瘤侵袭性的相关性分析  

Diagnostic Value of Ultrasonography in Papillary Thyroid Carcinoma and Its Correlation with Microvessel Density and Tumor Invasiveness

作　　者：贺春娇 许阳阳 李红霞[1] HE Chunjiao;XU Yangyang;LI Hongxia(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第6期937-940,共4页The Practical Journal of Cancer

摘　　要：目的研究超声对甲状腺乳头状癌的诊断价值及与微血管密度、肿瘤侵袭性的相关性。方法甲状腺乳头状癌患者60例为观察对象,另选取同期进行健康体检的健康人群60例作为对照组,比较两组的始增及峰值时间、峰值的增强强度及速率、50%倾斜率以及MVD水平之间的差异,并分析始增及峰值时间、峰值的增强强度及速率以及50%倾斜率与浸润程度以及MVD的相关性。结果观察组始增时间(t=19.246,P=0.000)、峰值时间(t=9.661,P=0.000)、增强速率(t=12.387,P=0.000)显著高于对照组,峰值增强强度(t=6.781,P=0.000)以及50%倾斜率(t=8.622,P=0.000)显著低于对照组;不同浸润程度患者的始增时间(F=5.257,P=0.000)、峰值时间(F=12.723,P=0.000)、峰值增强强度(F=10.284,P=0.000)、增强速率(F=11.505,P=0.000)以及50%倾斜率(F=12.337,P=0.000)之间的差异明显,不同浸润程度患者始增及峰值时间、增强速率由高至低分别是重度组、中度组以及轻度组,50%倾斜率以及峰值增强强度从高到低依次为轻度组、中度组以及重度组;不同浸润程度患者的MVD水平比较差异存在统计学意义,MVD水平从高到低依次为重度组、中度组以及轻度组;通过相关性分析,甲状腺乳头状癌患者的浸润程度以及MVD与始增时间、峰值时间、增强速率呈正相关,与50%倾斜率以及峰值增强强度呈负相关。结论超声指标与微血管密度、肿瘤侵袭性呈显著相关性,可作为甲状腺癌诊断的重要依据。Objective To study the diagnostic value of ultrasound in papillary thyroid carcinoma and its correlation with microvessel density and tumor invasion.Methods 60 patients with papillary thyroid carcinoma were selected as the observation objects,and 60 healthy people who underwent physical examination were selected as the control group.The difference of the onset and peak time,intensity and rate of peak intensification,50% tilt rate and MVD level between the 2 groups was compared.The correlation between the increase and peak time,the intensity and rate of peak strengthening,the 50% tilt rate with infiltration degree and MVD were analyzed.Results The start time(t=19.246,P=0.000),peak time(t=9.661,P=0.000),enhancement rate(t=12.387,P=0.000)of the observation group were significantly higher than those of the control group,peak enhancement intensity(t=6.781,P=0.000)and 50%tilt rate(t=8.622,P=0.000)were significantly lower than those in the control group.There were statistically significant differences in the onset time(F=5.257,P=0.000),peak time(F=12.723,P=0.000),peak enhancement intensity(F=10.284,P=0.000),enhancement rate(F=11.505,P=0.000)and 50% tilt rate(F=12.337,P=0.000)of patients with different degrees of invasion.The enhancement rate from high to low was in the order of severe group,moderate group and mild group.The 50% tilt rate and peak enhancement intensity from high to low were in the order of mild group,moderate group and severe group.The MVD levels of patients with different degrees of infiltration were statistically significant.By pairwise comparison,the MVD levels of patients from high to low were in the order of severe group,moderate group and mild group.Through correlation analysis,the degree of invasion and MVD of papillary thyroid cancer patients were positively correlated with the start time,peak time and enhancement rate,and negatively correlated with 50%tilt rate and peak enhancement intensity.Conclusion There is a significant correlation between ultrasound parameters and microvessel density,tumor

关 键 词：超声 微血管密度 甲状腺乳头状癌 肿瘤侵袭性 

分 类 号：R736.1[医药卫生—肿瘤]