Genome-wide associations, polygenic risk, and Mendelian randomization reveal limited interactions between John Henryism and cynicism  

作　　者：Richard R Chapleau 

机构地区：[1]Department of Genetics,NeuroStat Analytical Solutions,Great Falls,VA 22066,United States

出　　处：《World Journal of Medical Genetics》2023年第2期8-20,共13页世界医学遗传学杂志

摘　　要：BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interest.High scores on the JH scale and cynicism measures correlate with an increased risk of cardiovascular disease.High cynicism is also a hallmark of burnout syndrome,another known risk factor for heart disease.AIM To evaluate possible interactions between JH and cynicism hoping to clarify risk factors of burnout.METHODS We analyzed genetic and psychological data available from the Database of Genotypes and Phenotypes for genome-wide associations with these traits.We split the total available samples and used plink to perform the association studies on the discovery set(n=1852,80%)and tested for replication using the validation set(n=465).We used scikit-learn to perform supervised machine learning for developing genetic risk algorithms.RESULTS We identified 2,727,and 204 genetic associations for scores on the JH,cynicism and cynical distrust(CD)scales,respectively.We also found 173 associations with high cynicism,109 with high CD,but no associations with high JH.We also produced polygenic classifiers for high cynicism using machine learning with areas under the receiver operator characteristics curve greater than 0.7.CONCLUSION We found significant genetic components to these traits but no evidence of an interaction.Therefore,while there may be a genetic risk,JH is not likely a burnout risk factor.

关 键 词：CYNICISM Burnout syndrome John Henryism Genome-wide association study Polygenic risk score MACHINE-LEARNING 

分 类 号：R73[医药卫生—肿瘤]