Mosaicism of a novel variant in the ANKRD11 gene in a child with a mild KBG phenotype:A case report  

作　　者：Roberto Franceschi Francesca Rivieri Antonio Novelli Daniele Ferretti Adriano Anesi Massimo Soffiati Giulia Porretti Evelina Maines Mafalda Mucciolo Giorgio Radetti 

机构地区：[1]Department of Pediatrics,S.Chiara Hospital of Trento,APSS,Trento 38122,Italy [2]Genetic Unit,Laboratory of Clinical Pathology,Department of Laboratories,APSS,Trento 38122,Italy [3]Laboratory of Medical Genetics,Ospedale Pediatrico Bambino Gesù,Rome 00165,Italy [4]Human Genetics Laboratory,Ospedale Pediatrico Bambino Gesù,Rome 00165,Italy [5]Department of Pediatrics,S.Chiara General Hospital,APSS,Trento 38122,Italy [6]Department of Radiology,S.Chiara General Hospital,APSS,Trento 38122,Italy [7]Department of Pediatrics,General Hospital Bolzano,Marienklinik,Bolzano 39100,Italy

出　　处：《World Journal of Medical Genetics》2023年第2期21-27,共7页世界医学遗传学杂志

摘　　要：BACKGROUND KBG syndrome is likely underdiagnosed because of mild and non-specific features in some affected patients especially before the upper permanent central incisors eruption at about the age of 7-8 years.Somatic mosaicisms are usually recognized in the parents only after a typically affected son is diagnosed with KBG syndrome.We describe for the first time the mosaicism of a novel variant in a child with a mild KBG phenotype.CASE SUMMARY Our patient presented at 24 mo of age with short stature,hand abnormalities,facial dysmorphism and mild developmental delay.Pituitary hypoplasia and central hypothyroidism were also detected.By next generation sequencing(NGS)analysis we found a novel deletion in the ANKRD11 gene(c.4880_4893del.),that can be classified as likely pathogenic for the syndrome,with the percentage of mutated allele of 36%.We considered this finding as causative of the mild and non-specific phenotype for KBG syndrome in our patient,as previously reported in adults.A heterozygous variant in HESX1 gene,classified as variant of uncertain significance,but suspected of causing pituitary hypoplasia and hormonal deficiency,was also found.The patient started levothyroxine and growth hormone treatment.CONCLUSION The increased use of NGS analysis may expand the phenotypic spectrum of KBG syndrome because it allows genetic diagnosis of somatic mosaicisms also in children.

关 键 词：ANKRD11 KBG MOSAIC HESX1 CHILD Case report 

分 类 号：R36[医药卫生—病理学]