术前超声检查对甲状腺癌颈侧各区淋巴结转移的诊断效能  

Diagnostic efficacy of preoperative ultrasound in cervical lateral lymph nodes metastasis of thyroid cancer

作　　者：王梦丹 章双艳 王建华[1] WANG Mengdan;ZHANG Shuangyan;WANG Jianhua(Department of Thyroid and Breast Surgery,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院甲乳外科,江苏南京210028

出　　处：《分子影像学杂志》2023年第3期470-474,共5页Journal of Molecular Imaging

基　　金：江苏省卫生健康委科研课题(BJ18029);江苏省卫生健康委科研课题(M2020102);江苏省科技项目(BE2020726)。

摘　　要：目的探讨颈部超声对于甲状腺癌颈侧各区淋巴结转移的诊断价值。方法选取2020年8月~2021年11月于本院行甲状腺癌根治术的932例患者进行回顾性分析。所有患者均由我院经验丰富的超声医师进行至少两次颈部超声检查(分别为入院前与术前颈部超声检查)。收集患者两次颈部超声及颈部增强CT检查的影像学资料,以术后颈侧各区淋巴结组织的病理结果为金标准,采用SPSS 26.0和MedCacl 19.0.4软件进行统计学分析,计算并比较两次颈部超声、颈部增强CT检查在颈侧各区淋巴结转移的诊断效能指标及曲线下面积(AUC)。结果术前超声在颈侧Ⅲ、Ⅳ区淋巴结诊断的准确率、敏感度、特异性、假阳性率及假阴性率均优于入院前超声与颈部增强CT检查。术前超声在颈侧各区淋巴结的诊断AUC值均高于入院前超声与颈部增强CT检查。术前超声在颈侧Ⅲ、Ⅳ区淋巴结的AUC值均在0.80以上(分别为0.89、0.85),且与入院前超声与颈部增强CT检查的AUC值对比,差异有统计学意义(P<0.05)。术前超声在颈侧Ⅲ、Ⅳ区淋巴结的诊断价值优于其在颈侧Ⅱ、Ⅴ区淋巴结的诊断价值(AUC值分别为0.67、0.54)。结论术前由经验丰富的超声医师对甲状腺癌患者再次进行颈侧区淋巴结检查是重要且必要的。Objective To investigate the diagnostic value of cervical ultrasonography in the cervical lymph node metastasis of thyroid carcinoma.Methods A total of 932 patients who underwent radical thyroidectomy in our hospital from August 2020 to November 2021 were analyzed retrospectively.All patients were examined at least twice by experienced sonographers(preadmission and pre-operation respectively).The imaging data of cervical ultrasound and cervical enhanced CT were collected.According to the pathological results of cervical lymph nodes as the gold standard.SPSS 26.0 and MedCacl 19.0.4 were used statistical analysis and compare the diagnostic efficacy index and AUC value of cervical ultrasound and cervical enhanced CT in cervical lymph node metastasis.Results The diagnostic accuracy,sensitivity,specificity,false-positive rate and false-negative rate of pre-operation ultrasound in cervical lateralⅢandⅣlymph nodes were superior to those of pre-admission ultrasound and cervical enhanced CT.The AUC value of pre-operation ultrasound in cervical lateral lymph nodes was better than that of pre-admission ultrasound and cervical enhanced CT.The AUC values of pre-operation ultrasound in cervical lateralⅢandⅣlymph nodes were above 0.80(0.89 and 0.85,respectively),and the difference with the AUC values of pre-admission ultrasound and cervical enhanced CT was significant(P<0.05).The diagnostic value of pre-operation ultrasound in cervical lateralⅢandⅣlymph nodes was better than that in cervical lateralⅡandⅤlymph nodes(AUC value was 0.67 and 0.54,respectively).Conclusion It is important and necessary for patients with thyroid cancer to undergo cervical lateral lymph nodes exploration again by experienced sonographers before operation.

关 键 词：甲状腺癌 颈侧区淋巴结转移 超声 颈部增强CT 

分 类 号：R736.1[医药卫生—肿瘤]