光声成像联合光热治疗在肝癌诊治中的应用进展  

Application of photoacoustic imaging combined with photothermal therapy in the diagnosis and treatment of liver cancer

作　　者：庄填宇 焦嘉澎 连韵钰 方驰华[2] 黄振驹 曾宁[2] ZHUANG Tianyu;JIAO Jiapeng;LIAN Yunyu;FANG Chihua;HUANG Zhenju;ZENG Ning(The First Department of Hepatobiliary Surgery,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Digitalmedicine Clinical Engineering Technology Research Center of Guangdong/the Second Clinical Medical College of Southern Medical University,Guangzhou 510282,China)

机构地区：[1]南方医科大学第二临床医学院,广东广州510282 [2]南方医科大学珠江医院肝胆一区//广东省数字医学临床工程技术研究中心,广东广州510282

出　　处：《分子影像学杂志》2023年第3期548-553,共6页Journal of Molecular Imaging

基　　金：国家自然科学基金数学天元基金—“数学与医疗健康交叉重点专项(12026602)”;“十三五”国家重点研发计划数字诊断与治疗装备研发重点专项(2016YFC0106500);国家自然科学基金重大科研仪器研制项目(81627805);国家自然科学基金-广东联合基金(U1401254);广东省科技计划项目(2017ZC0110);广州市产学研协同创新重大专项(201604020144,201704020141)。

摘　　要：近年来,具有高分辨率、高对比度和高成像深度的光声成像技术在肝癌的诊疗中逐渐受到重视,光热治疗因光热转导剂在肿瘤的富集而有着高度特异性,其优秀的疗效也备受关注。本文主要介绍光声成像技术和光热治疗的基本原理以及具有高光声信号和良好光热转换效率的纳米诊疗剂,并展示了光声成像技术联合光热治疗,以纳米诊疗剂的形式在肝癌诊疗一体化中的应用。联合技术利用光声成像来监测纳米诊疗剂在肿瘤的富集,并通过光热效应来杀伤肿瘤细胞、调节肿瘤微环境、抑制肿瘤的转移复发,验证了联合技术在早期肝癌诊治的可行性和优势,推动其在临床上的实际应用。In recent years,photoacoustic imaging technology with high resolution,high contrast and high imaging depth has been paid more and more attention in the diagnosis and treatment of liver cancer.Photothermal therapy has also attracted more and more attention because of its high specificity and good therapeutic effect.This paper mainly introduces the basic principle of photoacoustic imaging technology and photothermal therapy,as well as nano-diagnostic agents with high photoacoustic signal and good photothermal conversion efficiency,and shows the application of photoacoustic imaging technology combined with photothermal therapy in the integration of diagnosis and treatment of liver cancer in the form of nano-diagnostic agents.Photoacoustic imaging is used to monitor the enrichment of nano-diagnostic agents in tumors,and laser irradiation is used to kill tumor cells,regulate tumor microenvironment and inhibit tumor metastasis and recurrence.The review describes the feasibility and advantages of combination technique in the diagnosis and treatment of hepatocellular carcinoma,and promote the practical application of combined technology clinically.

关 键 词：光声成像 光热治疗 诊疗一体化 纳米诊疗剂 

分 类 号：R735.7[医药卫生—肿瘤]