基于借氢策略构建苯并[4,5]咪唑并[1,2-c]喹唑啉的研究  

Synthesis of Benzo[4,5]imidazo[1,2-c]quinazoline Derivatives via Borrowing Hydrogen

作　　者：赵雯静 何航圳 丁旭君 董士琦 李江胜[1] ZHAO Wen-jing;HE Hang-zhen;DING Xu-jun;DONG Shi-qi;LI Jiang-sheng(School of Chemistry and Chemical Engineering,Changsha University of Science&Technology,Changsha 410114,China)

机构地区：[1]长沙理工大学化学化工学院,湖南长沙410114

出　　处：《精细化工中间体》2023年第2期32-35,共4页Fine Chemical Intermediates

基　　金：长沙理工大学校级创新训练项目。

摘　　要：发展了一种2-(邻硝基苯基)苯并咪唑与醇合成6-芳基苯并[4,5]咪唑并[1,2-c]喹唑啉的方法。该方法以Pd/C为催化剂、叔丁醇钠为添加剂,经醇脱氢-硝基还原-环化-脱氢等过程,该方法无需外加还原剂、操作简单安全、收率高。A method for the synthesis of 6-aryl benzo[4,5]imidazo[1,2-c]quinazoline derivatives from 2-(onitrophenyl)benzimidazole and benzyl alcohols was developed using Pd/C as catalyst,and sodium tert-butoxide as additive.This method involves a sequence of dehydrogenation-nitro reduction-cyclization-dehydrogenation,obviates extra reductants,and features easy and safe operation and high yield.

关 键 词：苯并咪唑 喹唑啉 醇 借氢 合成 

分 类 号：TQ25[化学工程—有机化工]