无功能性垂体腺瘤患者中COX-2和PGE_(2)的表达及与肿瘤侵袭性的关系  

Relationship between the expression of COX-2 and PGE_(2) and invasion in non-functional pituitary adenoma patients

作　　者：高莉 孙娟 刁艺[2] 韩东风[2] GAO Li;SUN Juan;DIAO Yi;HAN Dongfeng(Department of Endocrinology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China;Department of Neurosurgery,Xuzhou Central Hospital,Xuzhou,Jiangsu 221006)

机构地区：[1]徐州医科大学附属医院内分泌科,江苏徐州221002 [2]徐州市中心医院神经外科,江苏徐州221006

出　　处：《徐州医科大学学报》2023年第5期373-378,共6页Journal of Xuzhou Medical University

基　　金：徐州市科技计划项目(KC21254)。

摘　　要：目的探讨环氧化酶2(COX-2)和前列腺素2(PGE_(2))在无功能性垂体腺瘤(NFPA)患者中的表达及与肿瘤侵袭性的关系。方法选取2021年1月—2022年8月于徐州医科大学附属医院和徐州市中心医院行经蝶垂体肿瘤切除术的患者共82例。根据垂体瘤有无侵袭性,将上述患者分为侵袭性NFPA组和非侵袭性NFPA组。收集患者血清及其垂体肿瘤组织,进行相关实验室检查、血清及肿瘤组织匀浆COX-2、PGE_(2)水平测定。结果单因素分析显示,侵袭性NFPA组血清COX-2、PGE_(2)均显著高于非侵袭性NFPA组(P<0.05)。多因素Logistic回归分析显示,肿瘤直径、血清COX-2和血清PGE_(2)是NFPA发生浸润侵袭的独立危险因素(P<0.05)。血清COX-2、PGE_(2)均与垂体肿瘤组织匀浆COX-2、PGE_(2)水平呈正相关(P<0.05)。ROC曲线显示,血清COX-2、PGE_(2)以及二者联合诊断NFPA侵袭性的AUC分别为0.804、0.802、0.830(P均<0.05)。此外,NFPA患者血清COX-2、PGE_(2)均与肿瘤直径、Hardy-Wilson分级和分期、Knosp分级、Ki-67指数呈正相关(P<0.05)。结论NFPA患者血清COX-2、PGE_(2)水平与其肿瘤侵袭性密切相关,血清COX-2联合PGE_(2)水平升高可作为评价NFPA侵袭性的有效指标。Objective To investigate the expression of cyclooxygenase-2(COX-2)and prostaglandin E_(2)(PGE_(2))in patients with non-functional pituitary adenoma(NFPA)and their relationships with tumor invasion.Methods A total of 82 NFPA patients who underwent transsphenoidal resection of pituitary tumors in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from January 2021 to August 2022 were selected.According to the invasion of pituitary adenomas,the patients were divided into two groups:an invasive NFPA group and a non-invasive NFPA group.Clinical data and biochemical indicators were collected,and the levels of COX-2 and PGE_(2) in serum and tumor tissue homogenates were detected.Results According to one-factor analysis of variance,the invasive NFPA group showed remarkable increases in the levels of serum COX-2 and PGE_(2),compared with the non-invasive NFPA group(P<0.05).Multiple Logistic regression analysis showed that tumor diameter and the levels of serum COX-2 and PGE_(2) may be the risk factors of invasive NFPA(P<0.05).The levels of serum COX-2 and PGE_(2) were positively correlated with the levels of COX-2 and PGE_(2) in tumor tissue homogenates.The ROC curves showed that the AUC of COX-2,PGE_(2) and their combination for the diagnosis of invasive NFPA was 0.804,0.802,and 0.830(P<0.05).Moreover,clinical variable analyses revealed a significant correlation between the levels of serum COX-2 and PGE_(2) and tumor diameter,Hardy-Wilson grade and stage,Knosp grade and Ki-67 index in NFPA patients(P<0.05).Conclusions The levels of serum COX-2 and PGE_(2) in NFPA patients are closely correlated with invasion.Increases in the levels of serum COX-2 combined with PGE_(2) may provide effective evidence for assessing the invasive ability of pituitary adenomas.

关 键 词：环氧化酶2 前列腺素2 无功能性垂体瘤 侵袭性 肿瘤直径 

分 类 号：R735.3[医药卫生—肿瘤]