环状RNA与眼底增生性疾病的研究进展  

Research progress on circular RNA in fundus oculi proliferative diseases

作　　者：王艺敏(综述) 孙晓东(审校)[1] Wang Yimin;Sun Xiaodong(Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学附属第一人民医院眼科,上海200080

出　　处：《中华实验眼科杂志》2023年第5期516-519,共4页Chinese Journal Of Experimental Ophthalmology

摘　　要：眼底增生性疾病,如脉络膜新生血管、糖尿病视网膜病变、增生性玻璃体视网膜病变等,是以细胞增生或新生血管形成为病理特征,影响眼部正常结构及功能的一组疾病。环状RNA是一种非编码RNA,并被证实参与多种眼科疾病的病理生理过程。因此,环状RNA有希望成为治疗眼底增生性疾病的潜在靶点之一。本文就环状RNA的生理功能及其在糖尿病视网膜病变、增生性玻璃体视网膜病变、青光眼中神经胶质细胞增生等疾病和病理过程中的作用进行综述。Fundus oculi proliferative diseases,such as choroidal neovascularization,diabetic retinopathy,and proliferative vitreoretinopathy,are characterized by cell proliferation and neovascularization.It can lead to damage to the ocular structure and visual acuity.Circular RNA(CircRNA)is a non-coding endogenous RNA,which has been confirmed to be involved in the pathophysiological process of many ophthalmic diseases by recent studies.Thus,circRNA may become a promising target of fundus oculi proliferative diseases.This review concluded the physiological function of circRNA and its role in the physiological and pathological process of diabetic retinopathy,proliferative vitreoretinopathy and glaucoma-related glia proliferation.

关 键 词：环状RNA 眼科 糖尿病视网膜病变 增生性玻璃体视网膜病变 

分 类 号：R77[医药卫生—眼科]