CXCL11和CXCR3在宫颈癌患者中的表达及其与高危型人乳头状瘤病毒感染的关系  

Expression of CXCL11 and CXCR3 in cervical cancer patients and their association with high risk-human papillomavirus infection

作　　者：邓艳琴 高金菊 DENG Yanqin;GAO Jinju(Department of Gynecology,People′s Hospital of Jingmen City,Jingmen,Hubei 448000,China;Department of Obstetrics,People′s Hospital of Jingmen City,Jingmen,Hubei 448000,China)

机构地区：[1]荆门市人民医院妇科,湖北荆门448000 [2]荆门市人民医院产科,湖北荆门448000

出　　处：《国际检验医学杂志》2023年第11期1299-1304,共6页International Journal of Laboratory Medicine

基　　金：湖北省科技计划项目(2013CFC065)。

摘　　要：目的探讨宫颈癌患者CXC趋化因子配体11(CXCL11)、CXC趋化因子受体-3(CXCR3)表达及其与高危型人乳头状瘤病毒(HR-HPV)感染的关系。方法选取2019年5月至2022年5月该院诊治的宫颈癌患者75例为宫颈癌组,宫颈上皮内瘤变(CIN)患者78例为CIN组,宫颈炎患者52例为宫颈炎组。采用免疫组化法测定宫颈病变组织CXCL11、CXCR3表达,检测患者HR-HPV感染情况,分析CXCL11、CXCR3表达与HR-HPV感染的关系。结果宫颈癌组宫颈病变组织CXCL11、CXCR3阳性表达率及HR-HPV阳性感染率分别为85.33%、80.00%、90.67%,高于宫颈炎组的15.38%、11.54%、13.46%及CIN组的52.56%、50.00%、62.82%,差异均有统计学意义(P<0.05);CIN组CXCL11、CXCR3阳性表达率及HR-HPV阳性感染率高于宫颈炎组(P<0.05)。宫颈癌患者宫颈病变组织CXCL11、CXCR3表达及HR-HPV感染与淋巴结转移、分化程度有关(P<0.05)。宫颈癌患者中HR-HPV感染共68例,其中单一感染率为38.24%,多重感染率为61.76%;多重感染HR-HPV类型患者宫颈病变组织CXCL11、CXCR3阳性表达率高于单一感染HR-HPV类型患者(P<0.05)。宫颈癌患者宫颈病变组织CXCL11、CXCR3表达与HR-HPV感染有关(P<0.05);宫颈癌患者宫颈病变组织CXCL11表达与CXCR3有关(P<0.05)。结论CXCL11、CXCR3在CIN及宫颈癌患者的宫颈病变组织中表达较高,二者在宫颈癌患者中表达最高,CXCL11、CXCR3与HR-HPV感染相关,其可能是宫颈癌的治疗靶标。Objective To investigate the expression of CXC chemokine ligand 11(CXCL11)and CXC chemokine receptor-3(CXCR3)in cervical cancer patients and their relationship with high risk-human papillomavirus(HR-HPV)infection.Methods A total of 75 patients with cervical cancer diagnosed and treated in the hospital from May 2019 to May 2022 were selected as the cervical cancer group,78 patients with cervical intraepithelial neoplasia(CIN)were selected as the CIN group,and 52 patients with cervicitis were selected as the cervicitis group.The expression of CXCL11 and CXCR3 in cervical lesions were detected by immunohistochemistry.HR-HPV infection was detected.The relationship between CXCL11,CXCR3 expression and HR-HPV infection was analyzed.Results The positive expression rates of CXCL11 and CXCR3 and the positive infection rate of HR-HPV in the cervical cancer group cervical lesions were 85.33%,80.00%and 90.67%,respectively,which were higher than those in the cervicitis group(15.38%,11.54%,13.46%)and the CIN group(52.56%,50.00%,62.82%),and the differences were statistically significant(P<0.05).The positive expression rates of CXCL11 and CXCR3 and the positive infection rate of HR-HPV in CIN group were higher than those in cervicitis group(P<0.05).CXCL11,CXCR3 expression and HR-HPV infection in cervical lesions of patients with cervical cancer were related to lymph node metastasis and differentiation degree(P<0.05).There were 68 cases of HR-HPV infection in cervical cancer patients,the single infection rate was 38.24%,and the multiple infection rate was 61.76%.The positive expression rates of CXCL11 and CXCR3 in cervical lesions of patients with multiple HR-HPV infection were higher than those of patients with single HR-HPV infection(P<0.05).The expression of CXCL11 and CXCR3 in cervical lesions of patients with cervical cancer was related to HR-HPV infection(P<0.05).CXCL11 expression was correlated with CXCR3 expression in cervical lesions of patients with cervical cancer(P<0.05).Conclusion CXCL11 and CXCR3 are highly expressed

关 键 词：宫颈病变 CXC趋化因子配体11 高危型人乳头状瘤病毒 CXC趋化因子受体-3 

分 类 号：R737.33[医药卫生—肿瘤]